https://scholars.lib.ntu.edu.tw/handle/123456789/161831
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 動物中心 | en |
dc.contributor.author | Lu, H.-K. | en |
dc.contributor.author | Yeh, K.-C. | en |
dc.contributor.author | Wu, M.-F. | en |
dc.contributor.author | Li, C.-L. | en |
dc.contributor.author | Tseng, C.-C. | en |
dc.creator | 呂炫;吳銘芳;曾春祺 | zh-tw |
dc.creator | Lu, H.-K.; Yeh, K.-C.; Wu, M.-F.; Li, C.-L.; Tseng, C.-C. | en |
dc.date | 2008 | en |
dc.date.accessioned | 2009-12-23T09:31:13Z | - |
dc.date.accessioned | 2018-07-09T04:27:16Z | - |
dc.date.available | 2009-12-23T09:31:13Z | - |
dc.date.available | 2018-07-09T04:27:16Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/175239 | - |
dc.description.abstract | Background/aims: In the present study, we attempted to develop a simulated model to explore the causal effects of periodontal pathogens on skeletal homeostasis in postmenopausal osteoporosis. Methods: Fifty-three female adult ICR mice were randomly assigned to an experimental group ( ovariectomized) or a control group. A single injection of Porphyromonas gingivalis lipopolysaccharide (P. gingivalis-LPS, ATCC 33277) or Escherichia coli lipopolysaccharide (E. coli-LPS) was administered intraperitoneally 4 weeks after an ovariectomy. Concentrations of interleukin-6 (IL-6), osteoprotegerin (OPG ), and the receptor activator of nuclear factor-kappa B ligand (RANKL) in serum were subsequently analyzed using an enzyme-linked immunosorbent assay (ELISA). Results: Under stimulation with P. gingivalis-LPS or E. coli-LPS, the concentration of OPG rose in both groups. The serum level of RANKL showed a decreasing trend 24 h after the injection in both groups. After injection of P. gingivalis-LPS in both the experimental and control animals, the OPG : RANKL ratio increased 24 h after the booster (22.26-620.99, P < 0.05). The serum level of IL-6 in the experimental group significantly increased 1-6 h after administration of E. coli-LPS and 1-3 h after administration of P . gingivalis-LPS (P < 0.05). Conclusions: A single booster injection of P. gingivalis-LPS induced short-term changes in OPG, RANKL, and IL-6 serum levels in this ovariectomized mouse model. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | ORAL MICROBIOLOGY AND IMMUNOLOGY v.23 n.3 pp.220-225 | en |
dc.relation.ispartof | Oral Microbiology and Immunology | en_US |
dc.subject | interleukin-6 | en |
dc.subject | osteoporosis | en |
dc.subject | osteoprotegerin | en |
dc.subject | Porphyromonas gingivalis | en |
dc.subject | lipopolysaccharide | en |
dc.subject | receptor activator of nuclear factor-kappa B ligand | en |
dc.title | An Acute Injection of Porphyromonas Gingivalis Lipopolysaccharide Modulates the Opg/Rankl System and Interleukin-6 in an Ovariectomized Mouse Model | en |
dc.identifier.doi | 10.1111/j.1399-302X.2007.00415.x | - |
dc.relation.pages | 220-225 | - |
item.languageiso639-1 | en_US | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
顯示於: | 實驗動物中心 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。