|Title:||Do all the patients with vitamin B12 deficiency have pernicious anemia?||Authors:||Sun, Andy
Chang, Julia Y. -F.
|Keywords:||gastric parietal cell antibody;hemoglobin;macrocytosis;mean corpuscular volume;pernicious anemia;vitamin B12 deficiency||Issue Date:||2016||Start page/Pages:||23-27||Source:||Journal of Oral Pathology and Medicine||Abstract:||
BACKGROUND: Vitamin B12 deficiency may result in pernicious anemia (PA). This study evaluated whether all the patients with vitamin B12 deficiency had PA. ;METHODS: The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and mean corpuscular volume (MCV) in 90 vitamin B12-deficient patients were measured and compared with the corresponding data in 180 age-and sex-matched healthy control subjects. PA was defined by World Health Organization (WHO) as having an Hb concentration <13 g/dl formenand <12 g/dl for women, an MCV >= 100 fl, a serum vitamin B12 level <200 pg/ml, and serum gastric parietal cell antibody (GPCA) positivity. ;RESULTS: We found that 35 (38.9%) and 20 (22.2%) patients with vitamin B12 deficiency had deficiencies of Hb (men <13 g/dl, women <12 g/dl) and iron (<60 mu g/dl), respectively. Moreover, 65 (72.2%) and 37 (41.1%) patients with vitamin B12 deficiency had abnormally high blood homocysteine level (>12.7 mu M) and high MCV (>= 100 fl), respectively. In addition, 43 (47.8%) vitamin B12-deficient patients with had GPCA positivity. Patients with vitamin B12 deficiency had a significantly higher frequency of Hb or iron deficiency, of abnormally elevated blood homocysteine level or high MCV, and of GPCA positivity than healthy control subjects (all P-values < 0.001). However, only 17 (18.9%) of 90 vitamin B12-deficient patients were diagnosed as having PA by the WHO definition. ;CONCLUSION: Only 18.9% of patients with vitamin B12 deficiency are discovered to have PA by the WHO definition.
|Appears in Collections:||臨床牙醫學研究所|
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