https://scholars.lib.ntu.edu.tw/handle/123456789/162656
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 口腔生物研究所 | en |
dc.contributor.author | Ma, Y.L | en |
dc.contributor.author | Wang, H.L | en |
dc.contributor.author | Wu, H.C | en |
dc.contributor.author | Wei, C.L | en |
dc.contributor.author | Lee, E.H.Y | en |
dc.creator | 吳漢忠;李小媛 | zh-tw |
dc.creator | Ma, Y.L; Wang, H.L; Wu, H.C; Wei, C.L; Lee, E.H.Y | en |
dc.date | 2000 | en |
dc.date.accessioned | 2008-12-29T05:55:10Z | - |
dc.date.accessioned | 2018-07-09T05:27:23Z | - |
dc.date.available | 2008-12-29T05:55:10Z | - |
dc.date.available | 2018-07-09T05:27:23Z | - |
dc.date.issued | 2000 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/94754 | - |
dc.description.abstract | We have examined the relationship between brain-derived neurotrophic factor gene expression in the hippocampus and memory retention as well as long-term potentiation of rats. One-way inhibitory avoidance learning was adopted as the behavioural paradigm. Results revealed that brain-derived neurotrophic factor messenger RNA levels in the dentate gyrus of the hippocampus were markedly increased at 1 h, 3 h and 6 h post-training in rats showing good retention performance when compared with the poor retention controls. Direct injection of brain-derived neurotrophic factor antisense oligonucleotide into the dentate gyrus of the hippocampus before memory consolidation takes place markedly impaired retention performance in rats. It also significantly decreased brain-derived neurotrophic factor messenger RNA level in the dentate gyrus. The same antisense treatment also markedly reduced the amplitude and slope of excitatory postsynaptic potential as well as the brain- derived neurotrophic factor messenger RNA level in the dentate gyrus. These results suggest that hippocampal brain- derived neurotrophic factor gene expression plays an important role in the memory consolidation process and in the expression of long-term potentiation in rats. These results provide the first evidence to relate brain-derived neurotrophic factor gene expression and memory function in vertebrates. It further suggests that brain-derived neurotrophic factor gene expression is involved in behavioural plasticity. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | NEUROSCIENCE v.82 n.4 pp.957-967 | en |
dc.relation.ispartof | NEUROSCIENCE | - |
dc.subject | brain-derived neurotrophic factor | en |
dc.subject | gene expression | en |
dc.subject | memory retention | en |
dc.subject | long-term potentiation | en |
dc.subject | hippocampus | en |
dc.title | Brain-Derived Neurotrophic Factor Antisense Oligonucleotide Impairs Memory Retention and Inhibits Long-Term Potentiation in Rats | en |
dc.relation.pages | 957-967 | - |
dc.relation.journalvolume | v.82 | - |
dc.relation.journalissue | n.4 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
顯示於: | 口腔生物科學研究所 |
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