https://scholars.lib.ntu.edu.tw/handle/123456789/177151
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin, Tsun-Mei | en |
dc.contributor.author | Cheng, Tzong-Jih | en |
dc.contributor.author | Wu, Tsui-Hsun | en |
dc.contributor.author | Chang, Hsien-Chang | en |
dc.creator | Lin, Tsun-Mei; Cheng, Tzong-Jih; Wu, Tsui-Hsun; Chang, Hsien-Chang | - |
dc.date | 2005 | en |
dc.date.accessioned | 2010-06-02T03:05:03Z | - |
dc.date.accessioned | 2018-07-10T04:15:40Z | - |
dc.date.available | 2010-06-02T03:05:03Z | - |
dc.date.available | 2018-07-10T04:15:40Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/184914 | - |
dc.description.abstract | The activated partial thromboplastin time (aPTT) and the activated clotting time (ACT) were examined ex-vivo and in vitro, respectively, using a coagulometer based on a piezoelectric quartz crystal (PQC) sensor. A magno-mechanical and an optical coagulometer were employed to determine ACT and aPTT values in high-dose heparin therapy to evaluate the performance of the coagulometers. The correlations between aPTTs with a PQC coagulometer and ACTs with a magno-mechanical coagulometer were sufficient (>0.91) for a high-dose range (0-4 units/ml) of heparin in blood plasma and whole blood. Ex-vivo investigations of high-dose heparin therapy were also conducted to evaluate the analytical performance (sensitivity and specificity) of a PQC coagulometer, based on the receiver-operating characteristic. No false-positive or false-negative result was obtained in distinguishing the coagulation effect of 10,000 units of heparin administrated to subjects, using a suitable cut-off value (101 s) for whole blood aPTTs (WBaPTT) measured using a PQC coagulometer. The WBaPTT outperformed PLaPTT with a PQC coagulometer in terms of both safety (sensitivity = 100%) and accuracy (specificity = 97) (sensitivity = 100%, specificity = 87% in PLaPTT) and OCaPTT (sensitivity = 100%, specificity = 87%) with an optical coagulometer. ? 2005 Elsevier B.V. All rights reserved. | - |
dc.format | application/pdf | en |
dc.format.extent | 180469 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | en | en |
dc.language.iso | en_US | - |
dc.relation | Sensors and Actuators B: Chemical 109 (2): 270-277 | en |
dc.relation.ispartof | Sensors and Actuators B Chemical | en_US |
dc.subject | Activated clotting time; Activated partial thromboplastin time; Coagulometer; Heparin; Piezoelectric quartz crystal | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Blood; Cells; Crystals; Health risks; Monitoring; Patient treatment; Plasmas; Quartz; Activated clotting time; Activated partial thromboplastin time; Coagulometers; Heparin; Piezoelectric quartz crystals; Piezoelectric devices | - |
dc.title | Comparing a piezoelectric quartz crystal with an optical coagulometer in monitoring high-dose heparin therapy by determining whole blood activated partial thromboplastin time and activated clotting time | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.snb.2004.12.058 | - |
dc.relation.pages | 270-277 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/184914/1/07.pdf | - |
item.languageiso639-1 | en_US | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Biomechatronics Engineering | - |
crisitem.author.orcid | 0000-0002-3595-9866 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 生物機電工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。