https://scholars.lib.ntu.edu.tw/handle/123456789/177703
標題: | Carbazolothiophene-2-carboxylic acid derivatives as endothelin receptor antagonists | 作者: | Babu, Govindarajulu Yu, Hui-Ming Yang, Shyh-Ming Fang, Jim-Min |
關鍵字: | Coupling reactions;Endothelin;Samarium diiodide;Thio-phene;Indole | 公開日期: | 2004 | 起(迄)頁: | 1129-1132 | 來源出版物: | Bioorganic & Medicinal Chemistry Letters 14 | 摘要: | The SmI2-promoted three-component coupling reaction of thiophene-2-carboxylate, indole-2-carbaldehyde & acetophenone provides an expedient route to a series of tetracyclic carbazolothiophene compounds bearing the indole & thiophene rings. Among these samples, 9-benzyl-4-methyl-4-(4-hydroxyphenyl)-10-oxo-4,10-dihydrocarbazolo[2,3-b]thiophene-2-carboxylic acid (18) shows the most potent inhibition against the endothelin-1 induced increase of intracellular calcium ion concentration. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/2006111501232963 | 其他識別: | 246246/2006111501232963 | DOI: | 10.1016/j.bmcl.2003.12.067 |
顯示於: | 化學系 |
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