https://scholars.lib.ntu.edu.tw/handle/123456789/186524
DC Field | Value | Language |
---|---|---|
dc.contributor | 寄生蟲學科 | en |
dc.contributor.author | WU, MING-SHUN | en |
dc.contributor.author | LIAO, CHIEN-WEI | en |
dc.contributor.author | DU, WEN- YUAN | en |
dc.contributor.author | KAO, DING-CHAN | en |
dc.contributor.author | SU, KUA-EYRE | en |
dc.contributor.author | LIN, YUN-HO | en |
dc.contributor.author | CHANG, CHUN-CHAO | en |
dc.contributor.author | FAN, CHIA- KWUNG | en |
dc.contributor.author | FAN, CHIA-KWUNG | en |
dc.creator | 吳明順;廖建維;杜文圓;高定昌;蘇霩靄;林永和;張淳昭;范家堃 | zh-tw |
dc.creator | WU, MING-SHUN;LIAO, CHIEN-WEI;DU, WEN- YUAN;KAO, DING-CHAN;SU, KUA-EYRE;LIN, YUN-HO;CHANG, CHUN-CHAO;FAN, CHIA- KWUNG;FAN, CHIA-KWUNG | en |
dc.date | 2008 | en |
dc.date.accessioned | 2009-12-23T09:34:25Z | - |
dc.date.accessioned | 2018-07-11T03:51:32Z | - |
dc.date.available | 2009-12-23T09:34:25Z | - |
dc.date.available | 2018-07-11T03:51:32Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/175244 | - |
dc.description.abstract | Although toxocaral granulomatous hepatitis (TGH) characterized with a dominant-Th2 type immune response is a self-limiting disease, little is known concerning the role of fibrosis-related cytokine transforming growth factor-beta 1 (TGF-beta 1) in pathogenesis of TGH. A detailed histological and quantitatively immunohistochemical analysis of TGF-beta 1 , alpha-smooth muscle actins (alpha-SMA), and collagen was performed on the liver tissues from mice infected with Toxocara canis as assessed between day I and 42 weeks post-infection (DPI or WPI). TGF-beta 1 was detected mainly in infiltrating leukocytes in lesions with strong expressions from 4 to 16 WPI. Larvae per se also exhibited strong TGF-beta 1-like molecule expressions in the trial. Alpha-SMA was detected predominantly in hepatic stellate cells (HSC) which surrounded the lesions with moderate expressions largely throughout the period of the entire experiment. Collagen was observed to accumulate in inflammatory lesions and biliary basement with moderate to strong expressions from I WPI onwards in the trial. Since many evidences have indicated that leukocytes have the potential to influence HSC by producing TGF-beta 1 which can affect HSC to increase collagen synthesis in various liver diseases, we may propose that persistently elevated TGF-beta 1 expression in infiltrating leukocytes and active HSC with marked a-SMA expressions may contribute to healing of injured sites through up-stimulation of collagen deposition; in contrast, abnormally persistent collagen accumulation may cause irreversible fibrotic injury in the TGH. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | ACTA TROPICA v.105 n.3 pp.260-268 | en |
dc.relation.ispartof | ACTA TROPICA | - |
dc.subject | immunohistochemistry | en |
dc.subject | granulomatous hepatitis | en |
dc.subject | Toxocara canis | en |
dc.subject | transforming growth factor-beta 1 | en |
dc.subject | stellate cells | en |
dc.subject | alpha-smooth muscle actins | en |
dc.subject | collagen | en |
dc.subject | mice | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Enhanced Expression of Transforming Growth Factor-Beta 1 in Inflammatory Cells, Alpha-Smooth Muscle Actin in Stellate Cells, and Collagen Accumulation in Experimental Granulomatous Hepatitis Caused by Toxocara Canis in Mice | en |
dc.relation.pages | 260-268 | - |
dc.relation.journalvolume | v.105 | - |
dc.relation.journalissue | n.3 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
Appears in Collections: | 醫學系 |
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