https://scholars.lib.ntu.edu.tw/handle/123456789/187269
標題: | Lipoprotein(a) Is an Independent Risk Factor for Peripheral Arterial Disease in Chinese Type 2 Diabetic Patients in Taiwan | 作者: | TSENG, CHIN-HSIAO | 公開日期: | 2004 | 卷: | v.27 | 期: | n.2 | 起(迄)頁: | 517-521 | 來源出版物: | DIABETES CARE | 摘要: | OBJECTIVE - To examine the association between lipoprotein(a ) [Lp(a)] and peripheral arterial disease (PAD) and determine the optimal cutoff in Chinese type 2 diabetic patients in Taiwan. RESEARCH DESIGN AND METHODS - Serum Lp(a ) was determined in 557 type 2 diabetic patients (243 men and 314 women) recruited consecutively from a diabetes clinic at the National Taiwan University Hospital. Ankle- brachial index (ABI) <0.9 was diagnosed as PAD (n = 45) and< 0.8 as severe PAD (n = 20). Potential confounders included age, sex, BMI, waist-to-hip ratio (WHR), diabetes duration, insulin usage, smoking, hypertension, systolic and diastolic blood pressure, fasting plasma glucose (FPG), total cholesterol, triglycerides, and HDL and LDL cholesterol. RESULTS - The distribution of Lp(a) was right skewed and no significant differences for sex, WHR, insulin usage, smoking , hypertension, and systolic and diastolic blood pressure were observed. in men, log[Lp(a)] was correlated positively with age, duration, and total and LDL cholesterol ( borderline significant, P < 0.1) and negatively with BMI, triglycerides, and FPG (P < 0.1). In women, log[Lp(a) ] was correlated positively with total and LDL cholesterol and negatively with triglycerides and BMI (P < 0.1). ABI was significantly correlated with log[Lp(a)], especially in men or in patients with PAD. The optimal cutoff determined by discriminant analysis was 13.3 mg/dl. Patients with Lp(a) above this value had a 2.7-fold higher risk of PAD after multivariate adjustment. Lp(a) also significantly increased from no PAD to mild and severe PAD (17.1 +/- 14.4, 23.7 +/- 20.3, and 36.9 +/- 22.8 mg/ dl, respectively, P < 0.001). CONCLUSIONS - Lp(a) is an independent risk factor for PAD in type 2 diabetic patients in Taiwan. The optimal cutoff is 13.3 mg/dl. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88206 |
顯示於: | 醫學系 |
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