|Title:||Hepatitis B Virus Seropositivity Is Not Associated with Increased Risk of Carotid Atherosclerosis in Taiwanese||Authors:||YANG, KAI-CHIEN
SU, TA- CHEN
|Keywords:||Atherosclerosis;Carotid arteries;Hepatitis B;Taiwanese||Issue Date:||2007||Journal Volume:||v.195||Journal Issue:||n.2||Start page/Pages:||392-397||Source:||ATHEROSCLEROSIS||Abstract:||
Background: Chronic infection has been proposed to increase the risk of atherosclerosis in several experimental and epidemiological studies. However, the relationship of chronic hepatitis B vir-us (HBV) infection and atherosclerosis remains Controversial. We conducted this cross- sectional study to evaluate the association of carotid atherosclerosis with hepatitis B seropositivity. Methods and results: In this cross- sectional study, we collected data from subjects undergoing health examination, including B-mode carotid ultrasonography, hepatitis B surface antigen( HBsAg) status and assessment of traditional cardiovascular risk factors, at our institutes in Taiwan between 2002 and 2003. Cases with chronic hepatitis C had been excluded. Of the 508 eligible subjects, 87 ( 17.1%) were positive for HBsAg and only six of them were positive for HBeAg. Compared with HBsAg negative subjects, the ORs (and 95% CIs) for the subjects with chronic hepatitis B to have carotid atherosclerosis were 1.24 (0.73-2.10) indexed by the presence of carotid atherosclerotic plaque (Intima-media thickness, IMT >= 1.3 mm), 0.74 (0.38-1.42) by maximal common carotid artery IMT >= 75th percentile, and 1.09 (0.62 -1.90 ) by extracranial carotid artery atherosclerotic score> = 2, with the use of multivariate logistic regression analyses. Conclusion: Hepatitis B virus seropositivity was not associated with an increased severity of carotid atherosclerosis in Taiwanese. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
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