https://scholars.lib.ntu.edu.tw/handle/123456789/187482
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | TIEN, HWEI-FANG | en |
dc.creator | 田蕙芬;王秋華;李玢玉;劉敏枝;莊壽洺;陳耀昌;沈銘鏡;林東燦;林凱信;褚文銘 | zh_TW |
dc.creator | TIEN, HWEI-FANG;WANG, CHIU-HWA;LEE, FEN-YU;LIU, MING-CHI;CHUANG, SOU-MING;CHEN, YAO-CHANG;SHEN, MING-CHING;LIN, DONG-TSAMN;LIN, KAI-HSIN;CHUU, WEN-MIN | en |
dc.date | 1992 | en |
dc.date.accessioned | 2008-12-05T02:09:26Z | - |
dc.date.accessioned | 2018-07-11T04:54:51Z | - |
dc.date.available | 2008-12-05T02:09:26Z | - |
dc.date.available | 2018-07-11T04:54:51Z | - |
dc.date.issued | 1992 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/88324 | - |
dc.description.abstract | Among 72 Chinese patients with acute lymphoblastic leukemia (ALL), 50 had clonal chromosomal abnormalities. Structural abnormalities were detected in 42 patients: these included t (9;22) in 9, t(1;19) in 6, t(4;11) in 5, del(11)(q23) in 4, and del(6q) in 4. Adults had a higher incidence of t(9; 22) and t(1;19) but a lower incidence of t(4;11) and hyperdiploid greater than 50 karyotype than children. A significant difference was also noted in white blood cell ( WBC) count among various karyotypic groups. Patients with chromosomal abnormalities t(9;22), t(1;19), t(4;11) and del( 11) (q 23) had a shorter complete remission duration as compared with patients free of these abnormalities. Immunophenotyping was performed on 69 patients. All patients with t(9;22), t(1;19), and t(4;11) had B-lineage ALL restricted to certain stages of maturation: groups III and IV, groups IV and V, and group II, respectively (according to the classification of Foon and Tood). Among patients with t(9;22), t(4;11), and del(11)(q23), which have been considered to be associated with acute mixed-lineage leukemia, one each, respectively, showed myeloid antigen expression on the leukemic blasts (My+ ALL). No cross- lineage rearrangements of immunoglobulin (Ig) or T-cell receptor (TCR) genes were detected in these karyotypic subgroups of patients who underwent gene analysis. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CANCER GENETICS AND CYTOGENETICS v.59 n.2 pp.191-198 | en |
dc.relation.ispartof | CANCER GENETICS AND CYTOGENETICS | - |
dc.title | Cytogenetic Study of Acute Lymphoblastic Leukemia and Its Correlation with Immunophenotype, Genotype and Clinical Manifestation of the Disease | en |
dc.relation.pages | 191-198 | - |
dc.relation.journalvolume | v.59 | - |
dc.relation.journalissue | n.2 | - |
item.languageiso639-1 | en_US | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。