|Title:||Clonal chromosomal abnormalities as direct evidence for clonality in nasal T/natural killer cell lymphomas||Authors:||TIEN, HWEI-FANG
|Issue Date:||1997||Journal Volume:||v.97||Journal Issue:||n.3||Start page/Pages:||621-625||Source:||BRITISH JOURNAL OF HAEMATOLOGY||Abstract:||
Nasal T/natural killer (NK) cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe. The clonal nature of the infiltrating lymphoid cells is difficult to demonstrate because of the lack of immunologic markers ror clonalily and the absence of clonal T-cell receptor gene rearrangement in most cases. In this study, clonal chromosomal abnorrnalities were detected in the tumour cells from four patients with nasal T/NK cell lymphoma. This finding provided direct evidence for clonality of the disease. Moreover. nonrandom cytogenetic abnormalities, including isochromosome for the short arm (p) of chromosome 6, isochromosome for the long arm (q) of chromosome 1, partial deletion of 6q, and aberrations at 1 lq. were disclosed. Isochromosome 6p was the sole slruclural abnormalily in one patient. which may be a pathognomonic change in nasal lymphoma.
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.