https://scholars.lib.ntu.edu.tw/handle/123456789/188090
標題: | Methylation of the P15(Ink4b) Gene in Myelodysplastic Syndrome: It Can Be Detected Early at Diagnosis or during Disease Progression and Is Highly Associated with Leukaemic Transformation | 作者: | TIEN, HWEI-FANG | 關鍵字: | p15(INK4B);myelodysplastic syndrome;methylation;ACUTE LYMPHOBLASTIC-LEUKEMIA;HEMATOLOGICAL MALIGNANCIES;HUMAN CANCERS | 公開日期: | 2001 | 卷: | v.112 | 期: | n.1 | 起(迄)頁: | 148-154 | 來源出版物: | BRITISH JOURNAL OF HAEMATOLOGY | 摘要: | To investigate the time sequence of occurrence of p15(INK4B) gene methylation in myelodysplastic syndrome (MDS) and its correlation with leukaemic transformation and survival of patients, the methylation status of the p15(INK4B) promoter region was analysed in 50 patients and was serially studied in 22 of them. Of the 50 patients, 17 (34%) showed p15( INK4B ) gene methylation, first demonstrated at diagnosis or during follow -up. When FAB subtypes at the time of study were used in the analysis, the incidence of p15(INK4B) methylation in each risk group of MDS remained stable throughout the course: 0% for low-risk MDS [refractory anaemia (RA) and RA with ring sideroblasts] and from 23% at diagnosis to 30% for high- risk MDS [RA with excess of blasts (RAEB), RAEB in transformation and chronic myelomonocytic leukaemia] respectively. The incidence of p15(INK4B ) methylation rose to 60% at initial study and, finally, to 75 % in cases of acute myeloid leukaemia (AML) evolved from MDS . Most patients (69%) with p15(INK4B) methylation showed disease progression to AML; it could be detected before, at the time or after the diagnosis of leukaemic transformation. p15(INK4B) methylation in MDS patients implicated a shorter survival time in univariate analyses, but its prognostic significance disappeared in multivariate analyses. In conclusion, p15(INK4 B) methylation can be detected early at the diagnosis of MDS or acquired during disease progression. It may play an important role in the pathogenesis of some high-risk MDS and is related to leukaemic transformation of MDS. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/95136 |
顯示於: | 醫學系 |
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