https://scholars.lib.ntu.edu.tw/handle/123456789/189461
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 內科 | en |
dc.contributor.author | CHUANG, LEE-MING | en |
dc.creator | 莊立民 | zh-tw |
dc.creator | CHUANG, LEE-MING | en |
dc.date | 2005 | en |
dc.date.accessioned | 2009-09-29T03:17:01Z | - |
dc.date.accessioned | 2018-07-11T06:09:46Z | - |
dc.date.available | 2009-09-29T03:17:01Z | - |
dc.date.available | 2018-07-11T06:09:46Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/93051 | - |
dc.description.abstract | Objectives: Alternation in lipid metabolism can affect both insulin sensitivity and [beta]-cell function. Apolipoprotein A5 (APOA5) is an important determinant of lipid metabolism. The impact of the APOA5 gene on insulin sensitivity and [ beta]-cell function has not been examined. Methods: We examined the influence of 2 amino acid polymorphisms (V150M and G182C) in the APOA5 gene on insulin sensitivity and [ beta]-cell function in 67 glucose-tolerant white subjects. Insulin sensitivity index (ISI) and first- and second-phase insulin responses (1stIR and 2ndIR) were assessed using a hyperglycemic clamp technique. Results: We identified 59 VV and 8 VM subjects, and none had either the GC or CC genotype . Although no association was found with fasting lipid profile and plasma glucose concentrations during oral glucose tolerance test, the V150M was associated with higher 1stIR (P = 0.0010) and 2ndIR (P = 0.0016) and lower ISI (P = 0.0135). The associations of this polymorphism with 1stIR (P = 0 .0081) and 2ndIR (P = 0.0087) were independent of sex, age, and body mass index, but not ISI. Conclusions: The V 150M polymorphism had an independent influence on 1stIR and 2ndIR. Although the biologic consequence of this polymorphism remains to be determined, the V150M polymorphism in the APOA5 gene is a genetic marker for [beta ]-cell function. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | PANCREAS. v.30 n.4 pp.328-332 | en |
dc.relation.ispartof | PANCREAS | - |
dc.subject | apolipoproten A5 | en |
dc.subject | beta-cell function | en |
dc.subject | insulin sensitiveity | en |
dc.subject | single nucleotide polymorphism | en |
dc.subject | type 2(non-insulin-dependent) diabetes | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Impact of Apolipoprotein A5 Polymorphisms on Insulin Sensitivity and Beta -Cell Function | en |
dc.type | journal article | en |
dc.relation.pages | 328-332 | - |
dc.relation.journalvolume | v.30 | - |
dc.relation.journalissue | n.4 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
顯示於: | 醫學系 |
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