https://scholars.lib.ntu.edu.tw/handle/123456789/189608
標題: | Modifiable Risk Factors Control and Its Relationship with 1 Year Outcomes after Coronary Artery Bypass Surgery: Insights from the Reach Registry | 作者: | Mehta, R. H. Bhatt, D. L. Steg, Ph. G. Goto, S. Hirsch, A. T. Liau, C.-S. Rother, J. Wilson, P. W.F. Richard, A.-J. Eagle, K. A. Ohman, E. M. |
關鍵字: | Bypass; Coronary disease; Revascularization; Risk factors; Stroke | 公開日期: | 2008 | 起(迄)頁: | 3052-3060 | 來源出版物: | European Heart Journal | 摘要: | To evaluate the influence of achieving secondary prevention target treatment goals for cardiovascular (CV) risk factors on clinical outcomes in patients with prior coronary artery bypass surgery (CABG). Accordingly, we analysed treatment to target goals in patients with prior CABG and atherothrombotic disease or known risk factors (diabetes, hypertension, hypercholesterolaemia, smoking, obesity) enrolled in the global REduction in Atherothrombosis for Continued Health (REACH) Registry, and their association with 1 year outcomes. A total of 13 907 of 68 236 patients ( 20.4%) in REACH had a history of prior CABG, and 1 year outcomes data were available for 13 207 of these. At baseline < 25, 25-< 50, 50-< 75, and >= 75% risk factors were at goal in 3.7, 12.9, 31.7, and 51.7% of patients, respectively. One-year composite rates of CV death, non- fatal MI, non- fatal stroke were inversely related to the proportion of risk factors at goal at baseline (age, gender, and region adjusted rates 6.1, 5.6, 5.2, and 4.3% of patients with < 25, 25-< 50, 50-< 75, and > 75% risk factors at goal, respectively; P for trend 0.059). Risk-factor control varied greatly in CABG patients. Although CABG patients are frequently treated with appropriate therapies, these treatments fail to achieve an adequate level of prevention in many. This failure was associated with a trend for worse age-, gender-, and region-adjusted clinical outcomes. Thus, perhaps secondary prevention after CABG needs to focus on more comprehensive modification of risk factors to target goals in the hope of preventing subsequent CV events, and represents an opportunity to improve CV health. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/174615 | DOI: | 10.1093/eurheartj/ehn478 | SDG/關鍵字: | adult; aged; article; atherothrombosis; cardiovascular risk; cigarette smoking; clinical feature; controlled study; coronary artery bypass surgery; diabetes mellitus; disease registry; female; heart infarction; human; hypercholesterolemia; hypertension; major clinical study; male; mortality; obesity; outcome assessment; priority journal; risk management; stroke; thrombosis; Aged; Cardiovascular Diseases; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Recurrence; Registries; Risk Factors; Risk Reduction Behavior; Treatment Outcome; World Health |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。