|Title:||Prevalence of Atrial Fibrillation in Patients with Brugada Syndrome in Taiwan||Authors:||Juang, Jyh-Ming Jimmy
|Keywords:||Atrial fibrillation;Brugada syndrome;Taiwan||Issue Date:||2013||Journal Volume:||29||Journal Issue:||4||Start page/Pages:||311-316||Source:||Acta Cardiol. Sin.||Abstract:||
Purpose: The aim of this study was to assess the prevalence of atrial fibrillation (AF) in patients with Brugada syndrome (BrS) and their clinical characteristics in Taiwan.
Methods: The patient group consisted of 47 symptomatic BrS patients consecutively enrolled from 2000 to 2010. The definition of BrS patients with AF was a BrS patient with at least one episode of AF in a 12-lead electrogram or 24-hour holter (permanent, persistent or paroxysmal) during follow-up, or before diagnosis of BrS.
Results: Six BrS patients were identified with AF, and all of them were male. Two experienced sudden cardiac death (SCD), 2 presented with seizure and 4 with syncope. The mean age at onset of BrS was 47 +/- 16 years, similar to those BrS patients without AF (45 +/- 14, p = 0.67). Compared to those BrS patients without AF, significantly higher percentages of the BrS patients with AF presented with seizure and documented ventricular tachyarrhythmia (p = 0.02 and 0.03, respectively). Five of them had spontaneous Brugada type I electrogram, similar to those BrS patients without AF (p = 0.9). The SCN5A mutation rate is similar between BrS patients with AF and those without AF (p = 0.69). The prevalence of AF in BrS patients in Taiwan was 12.7% (6/47, 95% confidence interval 0.06-0.19) which is not significantly lower than the 20% prevalence found in the Caucasian population (p = 0.16).
Conclusions: BrS patients with AF had distinct clinical features from those patients without AF in Taiwan.
|Appears in Collections:||醫學系|
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