DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫學院-內科;臺大醫學院-病理學科暨研究所;臺大醫學院-基因體暨蛋白體醫學研究所; | en |
dc.contributor.author | Wang, Wen-Lung | en |
dc.contributor.author | Hong, Tse-Ming | en |
dc.contributor.author | Chang, Yih-Leong | en |
dc.contributor.author | Wu, Chen-Tu | en |
dc.contributor.author | Pan, Szu-Hua | en |
dc.contributor.author | Yang, Pan-Chyr | en |
dc.creator | Wang, Wen-Lung;Hong, Tse-Ming;Chang, Yih-Leong;Wu, Chen-Tu;Pan, Szu-Hua;Yang, Pan-Chyr | en |
dc.creator | 張逸良 ;楊泮池 ;潘思樺 | zh-tw |
dc.date | 2012 | en |
dc.date.accessioned | 2014-02-14T09:30:01Z | - |
dc.date.accessioned | 2018-07-11T07:08:00Z | - |
dc.date.available | 2014-02-14T09:30:01Z | - |
dc.date.available | 2018-07-11T07:08:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259771 | - |
dc.description.abstract | LCRMP-1, a novel isoform of CRMP-1, can promote cancer cell migration, invasion and associate with poor clinical outcome in patients with non-small-cell lung cancer (NSCLC). However, the underlying regulatory mechanisms of LCRMP-1 in cancer cell invasiveness still remain obscure. Here, we report that GSK3 beta can phosphorylate LCRMP-1 at Thr-628 in consensus sequences and this phosphorylation is crucial for function of LCRMP-1 to promote filopodia formation, migration and invasion in cancer cells. Impediment of Thr-628 phosphorylation attenuates the stimulatory effects of LCRMP-1 on filopodia forming, migration and invasion abilities in cancer cells; simultaneously, kinase-dead GSK3 beta diminishes regulation of LCRMP-1 on cancer cell invasion. Furthermore, we also found that patients with low-level Ser-9-phosphorylated GSK3 beta expression and high-level LCRMP-1 expression have worse overall survival than those with high-level inactive GSK3 beta expressions and low-level LCRMP-1 expressions (P<0.0001). Collectively, these results demonstrate that GSK3 beta-dependent phosphorylation of LCRMP-1 provides an important mechanism for regulation of LCRMP-1 on cancer cell invasiveness and clinical outcome. | en |
dc.format.extent | 110 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | PLoS One, 7(2) | en |
dc.relation.ispartof | PLoS One | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Phosphorylation of LCRMP-1 by GSK3 beta Promotes Filopoda Formation, Migration and Invasion Abilities in Lung Cancer Cells | en |
dc.relation.pages | - | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 2 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259771/1/index.html | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 醫學系
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