https://scholars.lib.ntu.edu.tw/handle/123456789/190919
標題: | Mechanisms of Sudden Cardiac Death Oxidants and Metabolism | 作者: | KAI-CHIEN YANG Kyle, John W. Makielski, Jonathan C. Dudley, Samuel C., Jr. Jr. |
關鍵字: | cardiac arrhythmias;death;sudden;cardiac;metabolism;oxidative stress | 公開日期: | 2015 | 起(迄)頁: | 1937-1955 | 來源出版物: | Circulation Research | 摘要: | Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/271075 | DOI: | 10.1161/CIRCRESAHA.116.304691 | SDG/關鍵字: | antiarrhythmic agent; calcium ion; ion channel; potassium channel; reactive oxygen metabolite; sodium channel; cardiovascular agent; ion channel; potassium; reactive oxygen metabolite; sodium; arrhythmogenesis; Article; calcium homeostasis; disease activity; electric activity; energy transfer; gap junction; heart arrhythmia; heart disease; heart muscle; heart muscle ischemia; heart muscle metabolism; heart repolarization; heart ventricle arrhythmia; human; membrane potential; metabolic regulation; metabolism; oxidation reduction state; oxidative stress; priority journal; regulatory mechanism; sudden cardiac death; Arrhythmias, Cardiac; calcium signaling; channel gating; complication; Death, Sudden, Cardiac; drug effects; heart mitochondrion; heart muscle conduction system; homeostasis; metabolic disorder; oxidation reduction reaction; pathophysiology; physiology; Arrhythmias, Cardiac; Calcium Signaling; Cardiovascular Agents; Death, Sudden, Cardiac; Gap Junctions; Heart Conduction System; Heart Diseases; Homeostasis; Humans; Ion Channel Gating; Ion Channels; Membrane Potentials; Metabolic Diseases; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Oxidative Stress; Potassium; Reactive Oxygen Species; Sodium |
顯示於: | 醫學系 |
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