https://scholars.lib.ntu.edu.tw/handle/123456789/191004
標題: | Splicing factor mutations predict poor prognosis in patients with de novo acute myeloid leukemia | 作者: | HSIN-AN HOU Liu, Chieh-Yu Kuo, Yuan-Yeh WEN-CHIEN CHOU CHENG-HONG TSAI CHIEN-CHIN LIN LIANG-IN LIN Tseng, Mei-Hsuan Chiang, Ying-Chieh Liu, Ming-Chih Liu, Chia-Wen JIH-LUH TANG MING YAO Li, Chi-Cheng SHANG-YI HUANG BOR-SHENG KO SZU-CHUN HSU Chen, Chien-Yuan Lin, Chien-Ting SHANG-JU WU WOEI TSAY HWEI-FANG TIEN |
關鍵字: | de novo AML;splicing factor mutations;prognosis;paired sample | 公開日期: | 2016 | 出版社: | Impact Journals LLC | 卷: | 7 | 期: | 8 | 起(迄)頁: | 9084 | 來源出版物: | Oncotarget | 摘要: | Mutations in splicing factor (SF) genes are frequently detected in myelodysplastic syndrome, but the prognostic relevance of these genes mutations in acute myeloid leukemia (AML) remains unclear. In this study, we investigated mutations of three SF genes, SF3B1, U2AF1 and SRSF2, by Sanger sequencing in 500 patients with de novo AML and analysed their clinical relevance. SF mutations were identified in 10.8% of total cohort and 13.2% of those with intermediate-risk cytogenetics. SF mutations were closely associated with RUNX1, ASXL1, IDH2 and TET2 mutations. SF-mutated AML patients had a significantly lower complete remission rate and shorter disease-free survival (DFS) and overall survival (OS) than those without the mutation. Multivariate analysis demonstrated that SF mutation was an independent poor prognostic factor for DFS and OS. A scoring system incorporating SF mutation and ten other prognostic factors was proved very useful to risk-stratify AML patients. Sequential study of paired samples showed that SF mutations were stable during AML evolution. In conclusion, SF mutations are associated with distinct clinic-biological features and poor prognosis in de novo AML patients and are rather stable during disease progression. These mutations may be potential targets for novel treatment and biomarkers for disease monitoring in AML. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/278739 https://www.scopus.com/record/display.uri?eid=2-s2.0-84961589389&doi=10.18632%2foncotarget.7000&origin=inward&txGid=21b80847bb0069e3ce8014408892882e |
ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.7000 |
顯示於: | 醫學系 |
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