https://scholars.lib.ntu.edu.tw/handle/123456789/191347
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 臺大醫院-內科部;臺大醫院-腫瘤醫學部;臺大醫學院;臺大醫學院-內科;臺大醫學院-腫瘤醫學研究所; | - |
dc.contributor.author | Kim, Seok Jin | en_US |
dc.contributor.author | Moon, Joon Ho | en_US |
dc.contributor.author | Kim, Hawk | en_US |
dc.contributor.author | Kim, Jin Seok | en_US |
dc.contributor.author | Hwang, Yu Yan | en_US |
dc.contributor.author | Intragumtornchai, Tanin | en_US |
dc.contributor.author | Issaragrisil, Surapol | en_US |
dc.contributor.author | Kwak, Jae Yong | en_US |
dc.contributor.author | Lee, Je Jung | en_US |
dc.contributor.author | Won, Jong Ho | en_US |
dc.contributor.author | Reksodiputro, Arry Harryanto | en_US |
dc.contributor.author | Lim, Soon Thye | en_US |
dc.contributor.author | ANN-LII CHENG | en_US |
dc.contributor.author | Kim, Won Seog | en_US |
dc.contributor.author | Kwong, Yok Lam | en_US |
dc.creator | Kim, Seok Jin;Moon, Joon Ho;Kim, Hawk;Kim, Jin Seok;Hwang, Yu Yan;Intragumtornchai, Tanin;Issaragrisil, Surapol;Kwak, Jae Yong;Lee, Je Jung;Won, Jong Ho;Reksodiputro, Arry Harryanto;Lim, Soon Thye;Cheng, Ann-Lii;Kim, Won Seog;Kwong, Yok Lam | en |
dc.creator | 鄭安理 | zh-tw |
dc.date | 2012 | - |
dc.date.accessioned | 2017-06-27T07:55:16Z | - |
dc.date.accessioned | 2018-07-11T07:16:42Z | - |
dc.date.available | 2017-06-27T07:55:16Z | - |
dc.date.available | 2018-07-11T07:16:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/280012 | - |
dc.description.abstract | This retrospective study concerns non-bacterial infections in Asian patients receiving alemtuzumab. The clinical data of 182 patients treated with alemtuzumab alone or alemtuzumab-containing chemotherapy between the years 2003 and 2009 was collected from six Asian countries. Alemtuzumab was used in the setting of frontline (n = 48) or salvage (n = 90) treatment, and as a part of the conditioning regimen for allogeneic stem cell transplant (n = 44). Reactivation of cytomegalovirus (66/182) and varicella zoster virus (25/182), and fungal infection (31/182) including invasive pulmonary aspergillosis, were the most common infectious complications in this retrospective analysis. Thus, we recommend routine prophylaxis with valganciclovir and itraconazole, especially when alemtuzumab is used in the conditioning regimen for allogeneic stem cell transplant. Pneumocystis jirovecii pneumonia (PJP) was found in four patients (3%, 4/122) receiving alemtuzumab as conditioning for stem cell transplant or salvage treatment. Three cases of hepatitis B virus reactivation were found in antigen-negative patients, and 16 cases of tuberculosis were observed. Infection is the major complication of alemtuzumab therapy, and these infectious complications are potentially severe and life-threatening. Based on our retrospective analysis, we have constructed a guideline for antimicrobial prophylaxis in Asian patients receiving alemtuzumab therapy. | - |
dc.language | en-us | - |
dc.relation | Leuk. Lymphoma, 53(8), 1515-1524 | - |
dc.relation.ispartof | Leukemia & Lymphoma | - |
dc.subject | Alemtuzumab | - |
dc.subject | infection | - |
dc.subject | prophylaxis | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aciclovir; alemtuzumab; cotrimoxazole; fluconazole; itraconazole; valaciclovir; valganciclovir; acute granulocytic leukemia; adolescent; adult; aged; allogeneic stem cell transplantation; antibiotic prophylaxis; aplastic anemia; article; Asian; child; chronic lymphatic leukemia; Cytomegalovirus; cytomegalovirus infection; drug dose comparison; female; Hepatitis B virus; herpes zoster; human; lung aspergillosis; major clinical study; male; mycobacteriosis; mycosis; myelodysplastic syndrome; Pneumocystis jiroveci; Pneumocystis pneumonia; priority journal; retrospective study; school child; side effect; T cell lymphoma; Varicella zoster virus; virus reactivation; Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Asia; Child; Cytomegalovirus Infections; Female; Herpes Zoster; Humans; Lymphoma; Male; Middle Aged; Mycoses; Retrospective Studies; Salvage Therapy; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous | - |
dc.title | Non-bacterial infections in Asian patients treated with alemtuzumab: a retrospective study of the Asian Lymphoma Study Group | - |
dc.identifier.doi | 10.3109/10428194.2012.659735 | - |
dc.relation.pages | 1515-1524 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Oncology | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.orcid | 0000-0002-9152-6512 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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