https://scholars.lib.ntu.edu.tw/handle/123456789/191986
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 外科 | en |
dc.contributor.author | LIANG, JIN-TUNG | en |
dc.contributor.author | 李伯皇 | zh_TW |
dc.creator | 梁金銅;黃國晉;鄭永銘;李伯皇;賴鴻緒;許輝吉 | zh_TW |
dc.creator | LIANG, JIN-TUNG;HUANG, KUO-CHIN;JENG, YUNG-MING;LEE, PO-HUANG;LAI, HONG-SHIEE;HSU, HEY-CHI | en |
dc.date | 2004 | en |
dc.date.accessioned | 2008-12-15T17:38:41Z | - |
dc.date.accessioned | 2018-07-11T09:14:55Z | - |
dc.date.available | 2008-12-15T17:38:41Z | - |
dc.date.available | 2018-07-11T09:14:55Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/91654 | - |
dc.description.abstract | Background: Tumour angiogenesis, cyclo-oxygenase (COX) 2 expression, K- ras mutation and p53 overexpression are commonly involved in colorectal tumorigenesis, but their interrelationship and clinicopathological effects remain inconclusive. Methods: Clinicopathological data from 114 consecutive patients with primary stage III colorectal cancer were evaluated prospectively. Microvessel density ( MVD) of the tumour was defined by counting the number of microvessels in hotspots, visualized by inummocytochemical staining of endothelial CD34. K-ras mutation was analysed by the restriction enzyme cleavage method. COX-2 expression and p 53 overexpression were determined by immunocytochemistry. Results: Increased MVD in hotspots was significantly associated with COX-2 expression (P < 0.001), K-ras mutation (P = 0.007) and p53 overexpression (P = 0.006 ). COX-2 expression was not associated with either K-ras mutation or p53 overexpression. Clinicopathologically, greater MVD and COX -2 expression were significantly associated with vascular invasion of cancer cells (MVD, P = 0.027 and COX-2 expression, P = 0.006), but p53 overexpression and K-ras mutation were not. Multivariate analysis indicated that greater MVD (P = 0.002) and p53 overexpression (P = 0.016) were significant independent predictors of tumour recurrence, whereas COX- 2 expression (P = 0.634) and K-ras mutation (P = 0.356) were not. Conclusion : Tumour angiogenesis may be associated with tumour metastasis and is significantly influenced by K-ras mutation , p53 overexpression and COX-2 expression in patients with colonic cancer. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BRITISH JOURNAL OF SURGERY v.91 n.3 pp.355~361 | en |
dc.relation.ispartof | BRITISH JOURNAL OF SURGERY | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Microvessel Density, Cyclo-Oxygenase 2 Expression, K-Ras Mutation and P53 Overexpression in Colonic Cancer | en |
dc.type | journal article | en |
dc.relation.pages | 355-361 | - |
dc.relation.journalvolume | v.91 | - |
dc.relation.journalissue | n.3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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