https://scholars.lib.ntu.edu.tw/handle/123456789/192121
標題: | 組織蛋白B,L及D在人類復發性肝癌中扮演的角色 | 作者: | 李伯皇 | 公開日期: | 31-七月-2001 | 出版社: | 臺北市:國立臺灣大學醫學院外科 | 摘要: | 在亞洲及南非地區肝癌是最嚴重的癌症。然而高達80%的原發性肝癌病人於五年內 會再併發復發性肝癌。就我們所知肝癌再復發的機制至今仍不十分清楚。組織蛋白脢(尤 其是組織蛋白脢B, L 及 D)分布於人類的淋巴結、腎、脾、肝、肺、腦、腸胃組織、心 及骨骼肌肉。有報告顯示當癌細胞藉由分解基片上的collagen 及elastin 而穿過基底膜以 達成其分化及轉移目的的過程中組織蛋白脢扮演了很重要的角色。在此篇報告中我們利 用 Western blotting 分析技術探討組織蛋白脢B, L 及 D 在原發性及復發性肝癌病人檢 體中的表現。結果顯示組織蛋白脢 L 在復發性肝癌中的表現明顯地較原發性肝癌強。當 復發性肝癌病人的 tumor stage 較原發性肝癌嚴重時,組織蛋白脢 L 的表現反而較弱。 其意義顯示組織蛋白脢 L 對於肝癌的再復發可能扮演一個重要的角色。 HCC is one of the most malignancies in Asia countries and South Africa. However, up to 80% of patients with primary HCC will recur again within five years. To our knowledge, the mechanism of HCC recurrence is still unclear. Cathepsins have been demonstrated in human lymph nodes, kidney, spleen, liver, lung, brain, gastrointestinal tissues, heart and skeletal muscle (5-7), especially Cathepsin B, L and D. Cathepsins were reported that played an important role in mediating the passage of malignant cells through the basement membrane by degrading collagen and elastin in the basal lamina resulting in invasion and metastasis. In the present study we investigated the expression of Cathepsin B, L and D in human patients with primary HCC and recurrent HCC by using of Western blotting. The result showed the expression of Cathepsin L in recurrent HCCs was significantly higher than those from primary HCCs in static. The tumor stage of recurrent HCCs was more advanced than of primary HCCs, the lower expression of the Cathepsin L was. It revealed that Cathepsin L may play an important role in human patients with HCC recurrence again. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/24442 | 其他識別: | 892314B002426 | Rights: | 國立臺灣大學醫學院外科 |
顯示於: | 醫學系 |
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892314B002426.pdf | 56.09 kB | Adobe PDF | 檢視/開啟 |
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