https://scholars.lib.ntu.edu.tw/handle/123456789/192139
標題: | 血管新生促進因子與抑制因子在人類胃癌的表現及相關性 Association of Placenta Growth Factor and Vascular Endothelial Growth Factor with Angiogenesis and Clinical Outcome in Human Gastr ic Cancer |
作者: | Chen, Chiung-Nien 陳炯年 |
公開日期: | 2002 | 出版社: | 臺北市:國立臺灣大學醫學院外科 | 摘要: | Angiogenesis is a very complex phenomenon and essential for the growth of solid tumors measuring more than a few millimeters. It permits rapid tumor growth and potential presence of tumor metastasis. Tumor angiogenesisis is a significant predictor of prognosis and hematogenous metastasis of patients with gastric cancer. Angiogenesis is not a passive process and is driven by many angiogenic factors produced by tumor. Of the known angiogenic factors, vascular endothelial growth factor (VEGF) have been shown to play an important role not only in angiogenesis and prognosis of different human tumors, but also in physiological and nonmalignant pathological conditions. Placenta growth factor (PlGF) is a member of the VEGF family of proangiogenic factors. VEGF binds with high affinity to two tyrosine kinase receptors: VEGF receptor-1 (Flt-1) and VEGFR-2 (Flk-1). PlGF binds with high affinity to Flt-1 but not to Flk-1. In contrast to VEGF, PlGF is not regulated by hypoxia and its physiological roles are largely unknown. PlGF is upregulated in placenta and during the active angiogenic phase of wound healing. Its upregulation has been found in human meningiomas, hemangioblastomas, melanoma, cervical squamous cell carcinoma and associated with angiogenesis in renal cell carcinoma. However, PlGF was down regulated in thyroid carcinoma, germ cell tumor, and cervical adenocarcinoma. To our knowledge, there has been no report on PlGF expression of human gastric cancer and its correlation with clinical outcome. Therefore, we quantitated expression of VEGF and PlGF in human gastric cancer tissues, which represent an important mechanism of angiogenesis, by enzyme immunoassays and compared with microvessel density and other clinicopathological variables as a basis for rational future therapeutic antiangiogenic approaches to gastric cancer treatment. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/24462 | 其他識別: | 902314B002339 | Rights: | 國立臺灣大學醫學院外科 |
顯示於: | 醫學系 |
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