https://scholars.lib.ntu.edu.tw/handle/123456789/192279
標題: | Thalidomide對鼠部份肝切除後肝臟再生及血管增生相關生長因子之影響 | 作者: | 胡瑞恆 | 公開日期: | 31-七月-2003 | 出版社: | 臺北市:國立臺灣大學醫學院外科 | 摘要: | 肝癌是台灣地區十大癌症死亡之第二位。雖然部份的病人可以利用外科手術加以 切除,但是術後腫瘤的復發仍是常常發生。另外,有些病人雖可手術切除主要的腫瘤, 但極可能仍存有影像學檢查所看不到的殘存腫瘤。這些復發或殘存腫瘤若要長大,勢 必要增加其血流供應。因此,有關血管增生之各種因子理論上都在此步驟中扮演一部 份的角色。(1-8) 而能夠抑制血管增生或新生的物質理論上也可能可以減慢或停止此步 奏之進行。在我們以前的實驗知道:在肝臟部份切除之後,會有很多的生長因子被刺 激表現。其中很多都直接或漸接與血管新生有關。這些生長因子是否會加快殘存腫瘤 的生長,值得我們的研究。另外,Thalidomide,一種可以抑制血管內皮生長因子的藥 物,其在一些血液之腫瘤及一些固體腫瘤也表現出抑制生長的效果。(9-16) 然而這些 報告都只是針對傳統療法失敗的病例,這些病人的腫瘤多已大到一個程度,已經超出 了血管新生的必要步驟。此時再使用Thalidomide 來抑制血管新生,可以預見的是缺乏 明顯的腫瘤消退的效果。若將Thalidomide 用在手術後減緩殘存腫瘤的生長,理論上應 該是有延緩腫瘤再生的效果。這研究也是很有興趣的話題。本實驗將利用鼠部分肝切 除之模式研究這些有興趣的課題。 Angiogenesis plays important roles in the cancer growth of many kinds, including hepatocellular carcinoma (HCC). It is an important step in the tumorogenesis and tumor metastasis. Some antibodies to the vascular growth factor and some naturally occurring anti-angiogenesis molecules are used now in the management of cancer treatment to those refractory cancers that are unresponsive to traditional treatment modalities. Promising effects are reported in these kinds of animal and clinical experiments. Thalidomide, a sedative with anti-angiogenesis activity, which was abandoned due to its teratogenesity to fetus, is now revised bcause of its anti-angiogenesis activity. As important as in tumorogenesis, angiogenesis is also an important step in the regeneration of liver after partial hepatectomy. In the treatment of HCC, thalidomide shows some promising effect in the control of tumor growth. On the other hand, whether thalidomide will interfere with liver regeneration after partial hepatectomy is an interesting topic to clinicians. In this experiment, we study the effect of thalidomide on liver regeneration after hepatectomy in a rat model. The effect of Thalidomide on the healing of surgical wound will be evaluated during the same experiment. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/24504 | 其他識別: | 912314B002259 | Rights: | 國立臺灣大學醫學院外科 |
顯示於: | 醫學系 |
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912314B002259.pdf | 15.48 kB | Adobe PDF | 檢視/開啟 |
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