https://scholars.lib.ntu.edu.tw/handle/123456789/192479
標題: | Association between N Acetyltransferase 2 (Nat2) Genetic Polymorphism and Development of Breast Cancer in Post-Menopausal Chinese Women in Taiwan | 作者: | HUANG, CHIUN-SHENG | 關鍵字: | CIGARETTE-SMOKING;ACETYLATION POLYMORPHISM;COLORECTAL-CANCER;ALLELIC LOSS;RISK;PHENOTYPE | 公開日期: | 1999 | 卷: | v.82 | 期: | n.2 | 起(迄)頁: | 175-179 | 來源出版物: | INTERNATIONAL JOURNAL OF CANCER | 摘要: | The incidence of breast cancer has increased greatly in Taiwan over the past 2 decades. Increased exposure to environmental carcinogens, including aryl aromatic amines, as a result of the economic boom, is suspected to be one factor contributing to this increase. The enzyme N- acetyltransferase 2 (NAT2) determines the rate of metabolism of aryl aromatic amines, and therefore the NAT2 slow acetylator genotype is associated with an increased risk of cancer. Our present case-control study of 150 breast cancer patients and 150 healthy controls in Taiwan was performed to explore the association between NAT2 genetic polymorphism and individual susceptibility to breast cancer. A structured questionnaire was used to collect relevant information regarding all known or suspected risk factors of breast cancer. The NAT2 genotype was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) assay in 139 cases and 133 controls, and 28.8% and 21.1%, respectively, were found to have sl |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96180 |
顯示於: | 醫學系 |
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