https://scholars.lib.ntu.edu.tw/handle/123456789/192569
標題: | Pyridoxal Phosphate-Responsive Epilepsy with Resistance to Pyridoxine | 作者: | KUO, MENG-FAI | 關鍵字: | LOW-DOSE CORTICOTROPIN;DEPENDENT SEIZURES;INFANTILE SPASMS | 公開日期: | 2002 | 卷: | v.26 | 期: | n.2 | 起(迄)頁: | 146-147 | 來源出版物: | PEDIATRIC NEUROLOGY | 摘要: | We present a female infant with seizures responsive to pyridoxal phosphate but that are resistant to pyridoxine. The mechanism by which pyridoxal phosphate controls seizures in this patient is unknown. Her seizures are perhaps not solely caused by pyridoxal phosphate deficiency. It is suggested that in addition to glutamic acid decarboxylase abnormality, the path from the absorption, transportation, phosphorylation , and oxidation of pyridoxine to pyridoxal phosphate in this patient might be defective. It should be considered whether pyridoxal phosphate can be the drug of choice instead of pyridoxine in treating patients suspected of pyridoxine-dependent epilepsy to reduce failure rate and further delay in seizure control. (C) 2002 by Elsevier Science Inc. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96271 |
顯示於: | 醫學系 |
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