https://scholars.lib.ntu.edu.tw/handle/123456789/192583
標題: | Sult1a1 Polymorphism and Esophageal Cancer in Males | 作者: | Wu, Ming-Tsang Wang, Yi-Ting Ho, Chi-Kung Wu, Deng-Chyang Lee, Yung-Chie Hsu, Hon-Ki Kao, Ein-Long Lee, Jang-Ming |
關鍵字: | esophageal cancer;sult1a1;genetic polymorphism | 公開日期: | 2003 | 卷: | v.103 | 期: | n.1 | 起(迄)頁: | 101-104 | 來源出版物: | INTERNATIONAL JOURNAL OF CANCER | 摘要: | Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A 1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a GA transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p < 0.0001). No subjects carried his/his. After adjusting for substance use and other covariates, individuals with arg/his had a 3.53-fold higher risk (95% CI = 2.12-5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04-4.80) among non- smokers , non-drinkers or non-chewers. Our findings suggest that the SULT1A1 his 213 allele is important in the development of esophageal cancer in men. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96285 |
顯示於: | 醫學系 |
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