https://scholars.lib.ntu.edu.tw/handle/123456789/193174
標題: | Annexin A4: A Novel Molecular Marker for Gastric Cancer with Helicobacter Pylori Infection Using Proteomics Approach | 作者: | Lin, Li-Ling CHIUNG-NIEN CHEN WEI-CHOU LIN PO-HUANG LEE KING-JEN CHANG YO-PING LAI JIN-TOWN WANG HSUEH-FEN JUAN |
關鍵字: | 2-DE;annexin A4;gastric cancer;helicobacter pylori;tructure modeling | 公開日期: | 2008 | 卷: | 2 | 期: | 4 | 起(迄)頁: | 619-634 | 來源出版物: | Proteomics - Clinical Applications | 摘要: | Helicobacter pylori was reported to be an important risk factor for the carcinogenesis of gastric cancer. Here, we used a proteomic approach to find differentially expressed proteins between the normal and tumor tissue of gastric cancer patients infected with H. pylori. In our results, we found annexin A4 was over-expressed in patients infected with H. pylori and was found in tumor cells, and over- expressed in gastric cancer SCM-1 cells after H. pylori infection. Ca2+ can be induced by H. pylori and interact with annexin A4 Ca2+ binding site to block the calmodulin- activated chloride conductance activation; therefore, it produces a new environment that benefits the malignant existence of H. pylori and raises the risk for gastric cancer. We also found interleuken-8 (IL-8) expression levels were increased in H. pylori infected SCM-1 cells. Combined with previous reports and our results, we summarize that the over-expression of annexin A4 in SCM-1 cells with H. pylori infection may subsequently induce IL-8 which can further cause tumor angiogenesis. In this paper, we show that annexin A4 is a potential novel molecular marker for gastric cancer with H. pylori infection, and our results may provide a new insight in the development of new anti-cancer drugs. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/174628 http://ntur.lib.ntu.edu.tw/bitstream/246246/174628/1/000007.pdf |
DOI: | 10.1002/prca.200780088 | SDG/關鍵字: | calcium ion; calmodulin; chloride; interleukin 8; lipocortin 2; lipocortin 4; molecular marker; amino acid sequence; article; binding site; cancer cell; cancer patient; cancer risk; chloride conductance; clinical article; controlled study; cytokine release; gastrectomy; Helicobacter infection; Helicobacter pylori; human; human cell; human tissue; immunohistochemistry; matrix assisted laser desorption ionization time of flight mass spectrometry; nonhuman; priority journal; protein analysis; protein expression; protein protein interaction; protein structure; proteomics; stomach cancer; stomach carcinogenesis; tandem mass spectrometry; tumor vascularization; two dimensional electrophoresis; Western blotting; Helicobacter pylori |
顯示於: | 醫學系 |
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