https://scholars.lib.ntu.edu.tw/handle/123456789/193315
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, Kuo-Hsin | en |
dc.contributor.author | Tung, Po-Yuan | en |
dc.contributor.author | Wu, Jiahn-Chun | en |
dc.contributor.author | Chen, Ying | en |
dc.creator | Chen, Kuo-Hsin;Tung, Po-Yuan;Wu, Jiahn-Chun;Chen, Ying;Chen, Po-Chun;Huang, Shih-Horng;Wang, Seu-Mei | en |
dc.date | 2008-08 | en |
dc.date.accessioned | 2011-02-11T08:59:21Z | - |
dc.date.accessioned | 2018-07-11T10:06:56Z | - |
dc.date.available | 2011-02-11T08:59:21Z | - |
dc.date.available | 2018-07-11T10:06:56Z | - |
dc.date.issued | 2008-08 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/223131 | - |
dc.description.abstract | Little attention has been paid to the role of adherens junctions (AJs) in acidic extracellular pH (pHe)-induced cell invasion. Incubation of HepG2 cells in acidic medium (pH 6.6) induced cell dispersion from tight cell clusters, and this change was accompanied by downregulation of β-catenin at cell junctions and a rapid activation of c-Src. Pretreatment with PP2 prevented the acidic pH-induced downregulation of β-catenin at AJ and in the membrane fractions. The acidic pHe-induced c-Src activation increased tyrosine phosphorylation of β-catenin and decreased the amount of β-catenin-associated E-cadherin. The depletion of membrane-bound β-catenin coincided with enhanced cell migration and invasion, and this acidic pHe-increased cell migration and invasion was prevented by PP2. In conclusion, this study characterizes a novel signaling pathway responsible for acidic microenvironment-promoted migration and invasive behaviors of cancer cells. ? 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language.iso | en_US | - |
dc.relation | Cancer Letters,267(1),37-48. | en |
dc.relation.ispartof | Cancer Letters | en_US |
dc.subject | β-Catenin; Acidic extracellular pH; Adherens junction; c-Src kinase; Cell migration; Invasion | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 4 amino 7 tert butyl 5 (4 chlorophenyl)pyrazolo[3,4 d]pyrimidine; beta catenin; protein tyrosine kinase; uvomorulin; article; cell culture; cell invasion; cell junction; cell migration; cell strain HepG2; controlled study; drug effect; gene activation; human; human cell; immunofluorescence; pH; priority journal; protein depletion; protein phosphorylation; Adherens Junctions; beta Catenin; Cadherins; Cell Line, Tumor; Cell Movement; Humans; Hydrogen-Ion Concentration; Phosphorylation; Signal Transduction; src-Family Kinases | - |
dc.title | An acidic extracellular pH induces Src kinase-dependent loss of β-catenin from the adherens junction | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.canlet.2008.03.005 | - |
dc.relation.pages | 37-48 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
顯示於: | 醫學系 |
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