https://scholars.lib.ntu.edu.tw/handle/123456789/193501
標題: | Pharmacokinetic Variability of Sirolimus in Taiwanese Renal Transplant Recipients | 作者: | CHUEH, SHIH-CHIEH WANG, SO-MONG LAI, MING-KUEN CHEN, JUN 王碩盟 |
公開日期: | 2004 | 卷: | v.36 | 期: | n.7 | 起(迄)頁: | 2058-2059 | 來源出版物: | TRANSPLANTATION PROCEEDINGS | 摘要: | To evaluate the pharmacokinetic variability of sirolimus ( Rapamycin, SRL ) in our renal transplant (RTx) recipients, dose-normalized trough concentration (C0) of SRL, and their intrasubject coefficients of variation (%CV) were analyzed. Thirty-eight patients were enrolled in regimens containing SRL. Concomitant immunosuppression included steroids(n cyclosporine (n mofetil (n ng/mL/mg. The intrasubject %CV of the dose- normalized C0 ranged from 14% to 88% and averaged 42% in our series. The mean dose-normalized C0 of SRL in our RTx recipients was much lower than that reported in Phase III trials. The intrasubject variation of dose- normalized C0 , even after administrating SRL for 6 months, could still be quite prominent. Thus, we suggest that, to maintain adequate therapeutic concentrations, periodic (monthly or bimonthly) SRL C0 measurement is necessary in Taiwanese ( Oriental) patients receiving SRL. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/87984 |
顯示於: | 醫學系 |
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