https://scholars.lib.ntu.edu.tw/handle/123456789/193539
標題: | Clinical Study of Oral Trazodone in the Treatment of 25 Impotent Patients 使用trazodone治療陽萎病人的臨床試驗 |
作者: | KUO, YUH-CHEN LIU, SHIH-PING HSIEH, JU-TON 郭育成 劉詩彬 謝汝敦 |
公開日期: | 1998 | 期: | n.1 | 起(迄)頁: | 7-11 | 來源出版物: | 中華民國泌尿科醫學會雜誌,v.9 | 摘要: | Trazodone is an oral antidepressant that has been reported to prolong erections of potent men and to improve erections of impotent patients. We administered 50 mg trazodone three times a day to twenty-five impotent patients. Four patients discontinued the medication within the first week due to severe drowsiness in three patients and difficulty in urination in one. Of the re-maining 21 patients, four were diagnosed with psychogenic impotence and 17 with organic im- potence. After four weeks of medication, the results were evaluated by questionnaires. The overall response rate to the mediction was 52.4%. Among the patients with organic impotence, there was no significant difference in response to the medication between the differ-ent age groups. However , the overall response rate to the medicaton was much higher in the patients who were impotent for 18 months or less (75 .0%) than in the patients who suffered from impotency more than 18 months (22.2%, p=0.0296). There was no obvious change n libido in thse patients. Side effects included a high percentage of drowsiness (84%) , weakness (48%), dry mouth (40%) and blurred vision (24%). Impaired renal function also occurred in two patients. In conclusion, trazodone is effective for some mpotent patients. It was more effective in treating patients who suffered from impotency for 18 months or less. Thus, the earlier impotence is diagnosed the better chance there is for successful treatment. Te side effects should be moni-tored carefully. A large double- blind series is needed to confirm the results and determine the optimal dose of trazodone. (J Urol R.O.C., 9:7-11,1998) |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/97068 |
顯示於: | 醫學系 |
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