|Title:||Safety and Immunogenicity of a Diphtheria, Tetanus, and Acellular Pertussis-Inactivated Poliovirus Vaccine/Haemophilus Influenzae Type B Combination Vaccine Administered to Taiwanese Infants At||Authors:||LIN, TZOU-YIEN
|Issue Date:||2003||Journal Volume:||v.26||Journal Issue:||n.5||Start page/Pages:||315-322||Source:||CHANG GUNG MEDICAL JOURNAL||Abstract:||
BACKGROUND: Combined vaccines are urgently needed to ensure compliance with the increasing number of recommended vaccines for children. We evaluated the safety and antibody response to a diphtheria, tetanus, and acellular pertussis- inactivated poliovirus vaccine/Haemophilus influenzae type b (DTaP-IPV/Hib) combination vaccine administrated to infants at 2, 4, and 6 months of age. METHODS: Sixty healthy infants between 6 and 12 weeks of age were enrolled. One group of vaccines received the DTaP-IPV/ Hib in a single injection, while another group concurrently received DTaP- IPV and Hib at separate injection sites. Solicited adverse events were monitored by parental observation and were recorded on a diary card. Levels of serum antibodies to DTaP and polyribosyl-ribitolphosphate- tetanus (PRP-T) antigens were collected before the first vaccine dose and 1 month after the third vaccine dose. RESULTS: The combined- injection group tended to have lower local reactions, and there was no increase in reactogenicity when compared with the separate- injection group. Seroconversion rates were 100% in both groups for all antigens, except for the anti-polio 2 antibody in the combined-injection group (96.4%). The combined-injection group had lower antibody levels of PRP (8 .45 microg/ml ) than did the separate-injection group (20.61 microg/ml). However, the percentage of vaccines achieving protective levels of antibody to PRP (> or = 0.15 microg/ml or > or = 1.0 microg/ml) was similar in both groups. CONCLUSIONS: DTaP-IPV/Hib may be safely and effectively administered to healthy infants, using a 2-, 4-, and 6-month vaccination schedule. This combined vaccine is cost- effective, more acceptable to parents and physicians, and minimizes distress to infants.
|Appears in Collections:||醫學系|
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