https://scholars.lib.ntu.edu.tw/handle/123456789/194340
標題: | Viremia Profiles in Children with Chronic Hepatitis B Virus Infection and Spontaneous E Antigen Seroconversion | 作者: | NI, YEN-HSUAN CHANG, MEI-HWEI CHEN, PEI -JER TSAI, KEH-SUNG HSU, HONG-YUAN CHEN, HUEY-LING TSUEI, DAW-JEN CHEN, DING-SHINN 蔡克嵩 |
關鍵字: | NATURAL-HISTORY;HEPATOCELLULAR-CARCINOMA;CORE PROMOTER;GENOTYPE;MUTANTS;UPDATE | 公開日期: | 2007 | 卷: | v.132 | 期: | n.7 | 起(迄)頁: | 2340-2345 | 來源出版物: | GASTROENTEROLOGY | 摘要: | Background & Aims: This study investigated the viremia profiles in children with chronic hepatitis B virus (HBV) infection and spontaneous heptitis B e antigen (HBeAg) seroconversion. Methods: Fifty-eight children with chronic HBV infection met the following criteria: normal alanine aminotransferase (ALT) level at enrollment, followed up for more than 10 years, no antiviral treatment, and having under -gone spontaneous HBeAg seroconversion during fol-low-up evaluation. They were grouped according to the post-HBeAg seroconversion HBV-DNA levels: (1) low viremia: transient or never 10 4 copies/mL or greater (n=35) (2) fluctuating high viremia: 104 copies/mL or greater at least twice at intrervals more than 1 year apart (n=23). Abdominal sonography, ALT, and HBV-DNA levels were assessed annually. Another 14 nonseroconverted children served as controls . The precore mutant (nt1896) and genotypes were examined. Results: The initial HBV-DNA level of the 58 serovonverters was 108.4±1.0 copies/mL and decreased to 102.9±2.0 copies/ mL at the end of fol-low-up period. Their mean ages at enrollment, at peak HBV-DNA, at peak ALT, at HBeAg serovonversion, and at final follow-up were 7.0±3.7, 13.4±5.8, 16.3±6.0 , 17.2±5.8, and 23.7±4.1 years, respedtively. The precore mutant appeared more often in the fluctuating- high-viremia group than in the low -viremia group (60.9% vs 22.9%, p=0.004). HBV genotypes had no effect on the viremia profiles. AfterHBeAg seroconverters had decreased viral loads, normal ALT levels, and uneventful coruses after HBeAg seroconversion. A longer follow-up period is necessary to elucidate the significance of HBeAg seroconversion occurring in childhood and young adulthood. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88629 |
顯示於: | 醫學系 |
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