https://scholars.lib.ntu.edu.tw/handle/123456789/194495
標題: | Longitudinal Study on Mutation Profiles of Core Promoter and Precore Regions of the Hepatitis B Virus Genome in Children | 作者: | NI, YEN-HSUAN CHANG, MEI-HWEI HSU, HONG-YUAN TSUEI, DAW-JEN |
公開日期: | 2004 | 卷: | v.56 | 期: | n.3 | 起(迄)頁: | 396-399 | 來源出版物: | PEDIATRIC RESEARCH | 摘要: | Precore nucleotide 1896 and core promoter mutations may account for hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, yet the mutational profiles of the core promoter are largely unknown in children. An age-matched, case-control study enrolled 110 chronic HBV-infected children, including 55 HBeAg seroconverters and 55 nonseroconverters. Precore and core promoter genes of HBV were sequenced and the serum viral genomes were genotyped from three serial serum samples of the seroconverters and from one serum sample of the nonseroconverters. Higher frequency of A1775G and G1799C mutation rates and lower frequency of A1752G mutation rate were found in the seroconverters. Precore 1896 mutation appeared more in seroconverters than in nonseroconverters ( 45.5% versus 10.9%; p < 0.001). 1762 + 1764 mutation rates were not different between the seroconverters (9.1%) and the nonseroconverters (5.5%). Genotype B was the major type. Genotype C was associated with core promoter 1762 + 1764 mutations in the seroconverter group (p = 0.023). The conclusions of this study include the following: 1) mutations of core promoter at nucleotide position 1752, 1775 , and 1799 have significant correlations with HBeAg seroconversion; 2 ) core promoter 1762 + 1764 mutations play a minimal role in HBeAg seroconversion; 3) precore 1896 mutant accounted for half of childhood HBeAg seroconversion; 4) genotype C is associated with 1762 + 1764 mutations during the process of HBeAg seroconversion. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88688 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。