https://scholars.lib.ntu.edu.tw/handle/123456789/194504
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | HUANG, LI-MIN | en |
dc.contributor.author | CHANG, LUAN-YIN | en |
dc.contributor.author | LU, CHUN-YI | en |
dc.contributor.author | HUANG, FU-YUAN | en |
dc.contributor.author | LIN, TZOU-YIEN | en |
dc.contributor.author | LEE, CHIN-YUN | en |
dc.creator | 黃立民;張鑾英;呂俊毅;黃富源;林奏延;李慶雲 | zh-tw |
dc.creator | HUANG, LI-MIN;CHANG, LUAN-YIN;LU, CHUN-YI;HUANG, FU-YUAN;LIN, TZOU-YIEN;LEE, CHIN-YUN | en |
dc.date | 2005 | en |
dc.date.accessioned | 2008-12-05T04:23:26Z | - |
dc.date.accessioned | 2018-07-11T17:50:21Z | - |
dc.date.available | 2008-12-05T04:23:26Z | - |
dc.date.available | 2018-07-11T17:50:21Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/88697 | - |
dc.description.abstract | PURPOSE: Disease caused by Bordetella pertussis is increasingly being identified among older children and adults in immunized populations, indicating a waning of the vaccine-induced immunity. These findings suggest the need for booster immunization of older children and adults. Modern acellular reduced-antigen-content vaccines have been developed, which can be given as a booster in individuals more than 4 years of age. This study was to assess the immunogenicity and reactogenicity of Boostrix , GlaxoSmithKline Biologicals' reduced-antigen-content diphtheria-tetanus acellular pertussis (dTpa) vaccine, when administered as a booster in healthy subjects previously primed with DTP vaccine. METHODS: Healthy Taiwanese children and adolescents aged 6-8 years and 15-20 years, previously primed with DTP vaccine, were enrolled. All received one dose of Boostrix. Two blood samples were taken from each of them, one before vaccination and one at 1 month after vaccination. Serum antibodies to diphtheria and tetanus toxoids and immunoglobulin G (IgG) antibodies against the pertussis components PT, FHA and PRN were measured by enzyme - linked immunosorbent assay (ELISA) technique. Adverse reactions following vaccination were recorded. RESULTS: A total of 180 subjects were recruited . The vaccine response rates to the pertussis antigens ranged between 89.0 -100%. There were no serious adverse events reported during the study period. CONCLUSIONS: The results of this study suggest that Boostrix may be safely and effectively administered as a booster dose to children previously primed with DTP vaccine. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF ADOLESCENT HEALTH v.37 n.6 pp.517.E1-.E5 | en |
dc.relation.ispartof | JOURNAL OF ADOLESCENT HEALTH | - |
dc.subject | Reduced-antigen-content dTpa vaccine | en |
dc.subject | Bordetella pertussis | en |
dc.subject | Taiwan | en |
dc.subject | Booster vaccination | en |
dc.subject | Adolescents | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Immunogenicity and Reactogenicity of a Reduced-Antigen-Content Diphtheria -Tetanus-Acellular Pertussis Vaccine in Healthy Taiwanese Children and Adolescents | en |
dc.type | journal article | en |
dc.relation.pages | - | - |
dc.relation.journalvolume | v.37 | - |
dc.relation.journalissue | n.6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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