https://scholars.lib.ntu.edu.tw/handle/123456789/194794
標題: | Thyroid Disease in Chinese Children with Iddm | 作者: | TSAI, WEN-YU LEE, JING-SHENG |
公開日期: | 1993 | 卷: | v.16 | 期: | n.9 | 起(迄)頁: | 1314-5 | 來源出版物: | DIABETES CARE | 摘要: | The association of IDDM with autoimmune thyroid disease has been well documented, and the screening for thyroid disorder in children with IDDM is recommended. In a recent issue of Diabetes Care, Wong reported an absence of thyroid disease in Chinese children with IDDM. The result is different from that of our previous report on the same topic. Now that we have more patients to testify to our previous results, we would like to share our experience in Taiwan. We have followed 65 Chinese children with IDDM at the pediatric endocrine clinic of the National Taiwan University Hospital. All patients (21 boys and 44 girls) were born in Taiwan. Their mean age at diabetes onset was 7.2 yr (range 0.3-15.0 yr), and the mean duration of follow-up was 4.2 yr (range 0. 1-14.3 yr). The diagnosis of IDDM was made according to NDDG criteria. Of our 65 patients, 50 (77%) have a history of ketoacidosis. Autoantibodies to thyroid microsomal antigen were determined by hemagglutination assay (Fujirebio , Tokyo, Japan). Those patients found to have thyroid microsomal autoantibodies also had their thyroid function evaluated by the determination of serum thyroxine concentration and serum TSH concentration. Serum thyroxine concentration was measured by RLA (Daiich Radioisotope, Tokyo, Japan), and serum TSH concentration was measured by immunoradiometric assay (Baxter Healthcare, Cambridge, MA). Thyroid microsomal autoantibodies were detected in 14 of 65 (22%) IDDM patients. No difference was noted between sex. Of the 14 patients with serological evidence of autoimmune thyroid disease, 1 (7%) had hyperthyroidism, and 1 (7%) had compensated hypothyroidism (elevated TSH with euthyroxineia) . They developed thyroid dysfunction 7 and 8 yr after the diagnosis of IDDM, respectively. Our current data confirm our previous notion that there is no ethnic difference in the association of autoimmune thyroid disease and IDDM. In our experience, the recommendation that all IDDM patients be screened for thyroid autoantibodies and that those with positive results undergo annual thyroid function tests is warranted, even in Chinese children with IDDM. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92529 |
顯示於: | 醫學系 |
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