https://scholars.lib.ntu.edu.tw/handle/123456789/194963
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | Lo, C.-H. | en |
dc.contributor.author | Lee, S.-C. | en |
dc.contributor.author | Wu, P.-Y. | en |
dc.contributor.author | Pan, W.-Y. | en |
dc.contributor.author | Su, J. | en |
dc.contributor.author | Cheng, C.-W. | en |
dc.contributor.author | Roffler, S. R. | en |
dc.contributor.author | Chiang, B.-L. | en |
dc.contributor.author | Lee, C.-N. | en |
dc.contributor.author | Wu, C.-W. | en |
dc.contributor.author | Tao, M.-H. | en |
dc.creator | 江伯倫;李君男;陶秘華 | zh-tw |
dc.creator | Lo, C.-H.; Lee, S.-C.; Wu, P.-Y.; Pan, W.-Y.; Su, J.; Cheng, C.-W.; Roffler, S. R.; Chiang, B.-L.; Lee, C.-N.; Wu, C.-W.; Tao, M.-H. | en |
dc.date | 2003 | en |
dc.date.accessioned | 2008-12-29T06:15:59Z | - |
dc.date.accessioned | 2018-07-11T17:55:29Z | - |
dc.date.available | 2008-12-29T06:15:59Z | - |
dc.date.available | 2018-07-11T17:55:29Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/94855 | - |
dc.description.abstract | The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from , those of IL-12. Although the antitumor activities of IL-12 are well characterized, the effect of IL-23 on tumor growth is not known. In this study, murine CT26 colon adenocarcinoma and B16F1 melanoma cells were engineered using retroviral vectors to release single-chain IL-23 (scIL -23) to evaluate its antitumor activity. In BALB/c mice, scIL-23-transduced CT26 cells grew progressively until day 26 to an average size of 521 +/- 333 mm(3), then the tumors started to regress in most animals, resulting in a final 70% rate of complete tumor rejection. scIL-23 transduction also significantly suppressed lung metastases of CT26 and B16F1 tumor cells. In addition, mice that rejected scIL-23- transduced tumors developed a memory response against subsequent wild-type tumor challenge. Compared with scIL-12- expressing CT26 cells, scIL-23-transduced tumors lacked the early response , but achieved comparable antitumor and antimetastatic activity. These results demonstrated that IL- 23, like IL-12, provided effective protection against malignant diseases, but it probably acted by different antitumor mechanisms. As a first step in identifying these antitumor mechanisms, tumor challenge studies were performed in immunocompromised hosts and in animals selectively depleted of various lymphocyte populations. The results showed that CD8(+) T cells, but not CD4(+) T cells or NK cells, were crucial for the antitumor activity of IL-23. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF IMMUNOLOGY v.171 n.2 pp.600-607 | en |
dc.relation.ispartof | JOURNAL OF IMMUNOLOGY | - |
dc.subject | IFN-GAMMA PRODUCTION | en |
dc.subject | TUMOR-REGRESSION | en |
dc.subject | IMMUNE-RESPONSE | en |
dc.subject | COLON- TUMOR | en |
dc.subject | T-CELLS | en |
dc.subject | INTERLEUKIN-12 | en |
dc.title | Antitumor and Antimetastatic Activity of Il-23 | en |
dc.type | journal article | en |
dc.relation.pages | 600-607 | - |
dc.relation.journalvolume | v.171 | - |
dc.relation.journalissue | n.2 | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
顯示於: | 醫學系 |
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