https://scholars.lib.ntu.edu.tw/handle/123456789/197007
標題: | Hormonal and Body-Size Factors in Relation to Breast Cancer Risk: A Prospective Study of 11,889 Women in a Low-Incidence Area | 作者: | WU, MEI-HSUAN CHOU, YU-CHING YU, JYH- CHERNG CHU, CHI-MING HSIEH, CHANG-YAO YOU, SAN-LIN CHEN, CHIEN-JEN SUN, CHIEN-AN |
關鍵字: | body size;breast cancer;hormonal risk factors;prospective study | 公開日期: | 2006 | 卷: | v.16 | 期: | n.3 | 起(迄)頁: | 223-229 | 來源出版物: | ANNALS OF EPIDEMIOLOGY | 摘要: | PURPOSE: This prospective cohort study of 11,889 women was conducted to determine significant factors associated with the risk of breast cancer among Chinese women in Taiwan, a low-incidence area. METHODS: In-person interviews were completed for subjects to solicit information on hormonal factors. Measurements of height, weight, and waist-and-hip circumferences were performed by well-trained assistants using standardized techniques. Cox proportional hazards models were employed to estimate relative risks ( RRs) and 95 % confidence intervals (CIs). RESULTS: During an average follow-up time of 10.3 years (range: 1 to 11 years) with an accumulation of 134,063 person-years, 104 incident breast cancer cases were identified through data linkage with national cancer registry profile. There was a significant elevation in breast-cancer risk with increasing duration of the interval between age at menarche and age at first full- term pregnancy (FFTP). Additionally, central adiposity reflected by hip circumference was a significant predictor of breast cancer in this Chinese female population. CONCLUSIONS: The findings of this study indicated common mechanisms responsible for the higher incidence of breast cancer in Western populations may also explain the risk of breast cancer development in Taiwan, a low-incidence area. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/93941 |
顯示於: | 醫學系 |
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