|Title:||Hepatitis B Post-Partum E Antigen Clearance in Hepatitis B Carrier Mothers: Correlation with Viral Characteristics||Authors:||LIN, HO-HSIUNG
KAO, JIA- HORNG
|Keywords:||carrier mothers;genotype;HBeAg;HBV-DNA;hepatitis B virus||Issue Date:||2006||Journal Volume:||v.21||Journal Issue:||n.3||Start page/Pages:||605-609||Source:||JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY||Abstract:||
BACKGROUND: The purpose of the present paper was to correlate hepatitis B virus (HBV) genotype, e antigen titer, HBV-DNA level and precore/basal core promoter mutations with post-partum e antigen clearance in hepatitis B e antigen (HBeAg)-positive carrier mothers. METHODS: A total of 40 consecutive HBeAg-positive carrier mothers were studied from January 2002 to January 2003. The blood samples were taken at delivery, 3-4 months and at 1 year after delivery, and the follow-up period was until 1 year after delivery. All sera were assayed for HBeAg, HBV-DNA level, HBV genotype and precore/basal core promoter mutations. The correlation between HBV characteristics and post-partum e antigen clearance was analyzed by Mann- Whitney, Pearson chi2 and multiple logistic regression tests. RESULTS: The mean age of the 40 HBeAg-positive carrier mothers was 29.9 +/- 5. 3 years with a mean parity of 1.4 +/- 0.7. Five of them ( group I) had post- partum e antigen clearance, which persisted thereafter, whereas the remaining 35 carrier mothers (group II) had persistent positivity of HBeAg during the follow-up period. The prepartum comparisons of HBV characteristics between groups I and II were comparable in terms of demographics and distributions of HBV genotype and precore/basal core promoter mutations. In contrast, group I carrier mothers had lower HBeAg titer and HBV-DNA level than group II carrier mothers (1:80 vs 1:4000, P = 0.02, and 3. 75 x 10(5) vs 3 x 10(8) copies/mL, P = 0.028, respectively). CONCLUSIONS: Post-partum e antigen clearance in HBeAg- positive carrier mothers is closely associated with prepartum low HBeAg titer or HBV-DNA level.
|Appears in Collections:||醫學系|
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