https://scholars.lib.ntu.edu.tw/handle/123456789/201388
標題: | Comparison of 18f-Fluoro-2-Deoxyglucose Positron Emission Tomography and Gallium-67 Citrate Scintigraphy for Detecting Malignant Lymphoma | 作者: | YEN, RUOH-FANG | 公開日期: | 2002 | 卷: | v.9 | 期: | n.2 | 起(迄)頁: | 321-5 | 來源出版物: | ONCOLOGY REPORTS | 摘要: | This study evaluates and compares the accuracy of positron emission tomography with 18F-fluoro-2-deoxyglucose (FDG-PET) and gallium-67 citrate (Ga-67) scintigraphy in identifying disease sites in patients with malignant lymphoma at initial diagnosis or relapse. Histology subgroups included low (n=5 ), intermediate (n=6), high-grade (n=5) non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) (n=14). Ann-Arbor staging included 7 patients in stage I, 8 in stage II, 9 in stage II, 6 in stage IV and 11 extra-nodal. In this study, before any therapy, 25 contemporaneous FDG-PET and Ga-67 scintigraphies were performed on patients with either NHL ( 16) or HD (14). One hundred and eleven sites of disease were correlated on a site-by-site basis in corresponding areas of FDG-PET and Ga-67 scintigraphy. Discordant FDG-PET and Ga -67 scintigraphic findings were correlated with CT/MRI and clinical evaluation . FDG-PET detected malignant lymphoma in 24/25 patients (sensitivity: 96.0 %). There was a false- negative FDG-PET result in only 1 patient with low- grade gastric malignant lymphoma. Ga-67 scintigraphy detected malignant lymphoma in 18/25 patients (sensitivity: 72.0%). There were false-negative Ga-67 scintigraphic results in 4 cases with low-grade non-Hodgkin's lymphoma, 2 cases with bone or bone marrow involvement, and 3 smaller disease sites . FDG-PET upstaged 6 patients in whom Ga-67 scintigraphy detected disease sites partially. In imaging lymphoma prior to therapy, FDG-PET had a higher sensitivity and detected significantly more disease sites when compared with Ga-67 scintigraphy in the initial evaluation of this group of patients. Upstaging of patients with FDG-PET may result in a change in treatment strategy. However, evaluation of the final sensitivity, specificity and accuracy of these imaging modalities will need a further study with a larger patient number. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/87934 |
顯示於: | 醫學系 |
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