https://scholars.lib.ntu.edu.tw/handle/123456789/201427
Title: | The Role of Fdg-Pet, Hmpao-Spet and Mri in the Detection of Brain Involvement in Patients with Systemic Lupus Erythematosus | Authors: | KAO, CHIA-HUNG LAN, JONNG-LIANG CHANG, LAI SHENG-PING LIAO, KO-KAUNG YEN, RUOH- FANG CHIENG, POON-UNG |
Keywords: | Fluorine-18 2-fluoro-2-deoxy-D-glucose;Positronemission tomography;Technetium-99m hexamethylpropylene amine oxime;Single-photon emission tomography;Magnetic resonance imaging;Systemic lupus erythematosus | Issue Date: | 1999 | Journal Volume: | v.26 | Journal Issue: | n.2 | Start page/Pages: | 129-134 | Source: | EUROPEAN JOURNAL OF NUCLEAR MEDICINE | Abstract: | Involvement of the brain is one of the most important complications of systemic lupus erythematosus (SLE); however , its diagnosis is difficult due to the lack of effective imaging methods. We combined three brain imaging modalities- - positron emission tomography with fluorine-18 2- fluoro-2- deoxy-d-glucose (FDG-PET), single-photon emission computed tomography with technetium-99m hexamethylpropylene amine oxime(HMPAO-SPET) and magnetic resonance imaging (MRI) – in order to detect brain involvement in SLE. Thirty-seven SLE patients, aged 22-45 years, were divided into three groups. Group 1 (G1) consisted of ten patients with major neuropsychiatric manifestations; group 2 (G2) consisted of 15 patients with minor manifestations; and group 3 (G3) consisted of 12 patients without manifestations. FDG-PET findings were abnormal in 51% of patients: 90% of G1, 67% of G2 and 0% of G3 patients respectively. HMPAO- SPET findings were abnormal in 62% of patients: 100% of G1, 73% of G2 and 17% of G3 patients respectively. MRI findings were abnormal in 35% of patients: 70% of G1, 40% of G2 and 0% of G3 patients respectively. Grey matter was more commonly involved than white matter; 62% of patients presented with lesions in the cerebral cortex, 27% with lesions in the basal ganglion, 5% with lesions in the cerebellum, and 19% with lesions in white matter. No white matter lesions were found on FDG-PET or HMPAO-SPET . However, in 19% of patients, MRI demonstrated abnormally high signal lesions in white matter. Forty-three percent of cases had positive serum anticardiolipin antibodies (ACA). However, ACA was not related to FDG-PET, HMPAO-SPET or MRI findings. It may be concluding that HMPAO-SPET is a more sensitive tool for detecting brain involvement in SLE patients when compared with FDG-PET or MRI. However, MRI is necessary for detecting lesions in white matter. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96937 |
Appears in Collections: | 醫學系 |
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