https://scholars.lib.ntu.edu.tw/handle/123456789/201448
Title: | Comparing Whole Body 18f-2-Deoxyglucose Positron Emission Tomography and Technetium-99m Methylene Diphosphate Bone Scan to Detect Bone Metastases in Patients with Renal Cell Carcinomas - a Preliminary Report | Authors: | YEN, RUOH-FANG | Keywords: | 18F-2-deoxyglucose positron emission tomography;technetium- 99m methylene diphosphate;bone scan;bone;CANCER;MARROW | Issue Date: | 2002 | Journal Volume: | v.128 | Journal Issue: | n.9 | Start page/Pages: | 503-506 | Source: | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | Abstract: | Purpose: Conventional technetium-99m methylene diphosphate whole body bone scan (bone scan) has a high sensitivity but a poor specificity to detect bone metastases. However, positron emission tomography with 18F-2- deoxyglucose (FDG- PET) can offer superior spatial resolution and improved specificity. We have attempted to evaluate the usefulness of FDG-PET for detecting bone metastases in renal cell carcinomas (RCC) and to compare FDG-PET results with bone scan findings. Methods: Eighteen patients were selected for this study with biopsy-proven RCC. They were suspected of having bone metastases and were undergoing bone scan and FDG -PET to detect bone metastases. The final diagnoses of bone metastases were established by operative, histopathological findings or clinical follow-up longer than 1 year by additional radiographs or following FDG-PET/ bone scan findings showing progressive and extensive widespread bone lesions. Results: A total of 52 bone lesions including 40 metastatic and 12 benign bone lesions found on either FDG- PET or bone scan were evaluated. FDG-PET could accurately diagnose all 40 metastatic and 12 benign bone lesions. Bone scan could accurately diagnose only 31 metastatic bone lesions. Diagnostic sensitivity and accuracy of FDG-PET were 100% and 100%, respectively, and bone scan were 77.5% and 59.6%, respectively. Conclusions: Our data suggest that FDG- PET has a higher sensitivity and a better accuracy than that of bone scan to detect bone metastases in patients with RCC. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96958 |
Appears in Collections: | 醫學系 |
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