https://scholars.lib.ntu.edu.tw/handle/123456789/201469
標題: | Using Tc-99m Hmpao Brain Spect to Evaluate the Effects of Anticoagulant Therapy on Regional Cerebral Blood Flow in Primary Antiphospholipid Antibody Syndrome Patients with Brain Involvement - a Preliminary Report | 作者: | YEN, RUOH-FANG | 關鍵字: | anticoagulant therapy;primary antiphospholipid antibody syndrome regional cerebral;Tc-99m HMPAO brain SPECT | 公開日期: | 2003 | 卷: | v.23 | 期: | n.6 | 起(迄)頁: | 301-304 | 來源出版物: | RHEUMATOLOGY INTERNATIONAL | 摘要: | Technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO ) brain single photon emission computed tomography (SPECT) was used to evaluate the effects of anticoagulant therapy ( ACT) on regional cerebral blood flow (rCBF) in patients with primary antiphospholipid antibody syndrome ( PAPS). Sixteen female PAPS patients with neuropsychiatric manifestations and hypoperfusion lesions demonstrated on initial Tc-99m HMPAO brain SPECT images were enrolled in this study. Follow -up Tc-99m HMPAO brain SPECT images were performed 1 month after ACT. Meanwhile, serum anticardiolipin antibodies (ACA) were measured before and after ACT. Before ACT, 14 (87.5% ) patients had positive ACA. After ACT, all 16 PAPS patients showed decreased serologic findings, and their neuropsychiatric manifestations subsided . After ACT, 11 (68 .8%) patients showed complete recovery of regional cerebral blood flow (rCBF) and five (31.2%) patients showed partial recovery in the follow-up Tc-99m HMPAO brain SPECT images. This type of imaging is a logical and objective tool for measuring the effects of ACT in PAPS patients with brain involvement by determining changes in rCBF. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96994 |
顯示於: | 醫學系 |
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