https://scholars.lib.ntu.edu.tw/handle/123456789/201522
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 放射線科 | en |
dc.contributor.author | YEN, RUOH-FANG | en |
dc.contributor.author | WU, VIN-CENT | en |
dc.contributor.author | LIU, KAO- LANG | en |
dc.contributor.author | CHENG, MEI-FANG | en |
dc.contributor.author | WU, YEN-WEN | en |
dc.contributor.author | CHUEH, SHIH-CHIEH | en |
dc.contributor.author | LIN, WEI-CHOU | en |
dc.contributor.author | WU, KWAN-DUN | en |
dc.contributor.author | TZEN, KAI-YUAN | en |
dc.contributor.author | LU, CHING-CHU | en |
dc.contributor.author | YEN, RUOH -FANG | en |
dc.creator | 顏若芳;吳允升;劉高郎;鄭媚方;吳彥雯;闕士傑;林維洲;吳寬墩;曾凱元;路景竹 | zh-tw |
dc.creator | YEN, RUOH-FANG;WU, VIN-CENT;LIU, KAO- LANG;CHENG, MEI-FANG;WU, YEN-WEN;CHUEH, SHIH-CHIEH;LIN, WEI-CHOU;WU, KWAN-DUN;TZEN, KAI-YUAN;LU, CHING-CHU;YEN, RUOH -FANG | en |
dc.date | 2009 | en |
dc.date.accessioned | 2010-06-23T06:22:15Z | - |
dc.date.accessioned | 2018-07-12T05:37:28Z | - |
dc.date.available | 2010-06-23T06:22:15Z | - |
dc.date.available | 2018-07-12T05:37:28Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/185914 | - |
dc.description.abstract | The 2 main causes of primary aldosteronism (PA) are aldosterone-producing adenoma (APA) and idiopathic adrenal hyperplasia (IAH). Dexamethasone- suppression (131)I-6beta- iodomethyl-19-norcholesterol (NP-59) adrenal scintigraphy can assess the functioning of the adrenal cortex. This study evaluated the diagnostic usefulness of NP-59 SPECT/CT in differentiating APA from IAH and in predicting postadrenalectomy clinical outcome for PA patients who had inconclusive adrenal venous sampling (AVS) and CT results . METHODS: We retrospectively reviewed the 31 adrenal lesions of 27 patients (age range, 33-71 y; mean age +/- SD, 50.4 +/ - 10.9 y) who had been clinically confirmed (by saline infusion and captopril tests) to have PA, had inconclusive CT and AVS test results, and had undergone NP-59 imaging before adrenalectomy. The accuracy of NP-59 imaging was determined by comparison with histopathologic findings. RESULTS: NP-59 SPECT/CT gave us 18 true-positive, 3 false- positive, 6 true-negative, and 4 false- negative results. Compared with planar imaging, SPECT/CT significantly improved diagnostic accuracy and prognostic predicting ability (P = 0.0390 and P = 0.0141, respectively). The NP-59 results were negative for 7 of the 23 patients with unilateral adrenal lesions, and none of these 7 patients had shown postsurgical clinical improvement. CONCLUSION: NP-59 SPECT/CT is an effective imaging tool for differentiating APA from IAH in PA patients whose CT and AVS results are inconclusive. Our results suggest that patients with presurgically negative NP-59 results should be treated medically and that noninvasive NP-59 SPECT/CT may be suited for use as the first lateralization modality after CT in patients with clinically confirmed PA. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | THE JOURNAL OF NUCLEAR MEDICINE v.50 n.10 pp.1631-1637 | en |
dc.relation.ispartof | THE JOURNAL OF NUCLEAR MEDICINE | - |
dc.subject | NP-59 | en |
dc.subject | SPECT/CT | en |
dc.subject | primary aldosteronism | en |
dc.subject | adrenal adenoma | en |
dc.title | 131i-6beta-Iodomethyl-19-Norcholesterol Spect/Ct for Primary Aldosteronism Patients with Inconclusive Adrenal Venous Sampling and Ct Results | en |
dc.relation.pages | 1631-1637 | - |
dc.relation.journalvolume | v.50 | - |
dc.relation.journalissue | n.10 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
顯示於: | 醫學系 |
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