https://scholars.lib.ntu.edu.tw/handle/123456789/202118
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 檢驗醫學科 | en |
dc.contributor.author | CHOU, WEN-CHIEN | en |
dc.contributor.author | CHIANG, I-PING | en |
dc.contributor.author | TANG, JIH-LUH | en |
dc.contributor.author | SU, IH-JEN | en |
dc.contributor.author | HUANG, SHANG-YI | en |
dc.contributor.author | CHEN, YAO-CHANG | en |
dc.contributor.author | LIU, MING-CHI | en |
dc.contributor.author | LEE, FEN-YU | en |
dc.contributor.author | WANG, CHIU-HWA | en |
dc.contributor.author | SHEN, MING-CHING | en |
dc.contributor.author | CHUANG, SOU-MING | en |
dc.contributor.author | TIEN, HWEI-FANG | en |
dc.creator | 周文堅;江宜平;唐季祿;蘇益仁;黃聖懿;陳耀昌;劉敏枝;李玢玉;王秋華;沈銘鏡;莊壽洺;田蕙芬 | zh_TW |
dc.creator | CHOU, WEN-CHIEN;CHIANG, I-PING;TANG, JIH-LUH;SU, IH-JEN;HUANG, SHANG-YI;CHEN, YAO-CHANG;LIU, MING-CHI;LEE, FEN-YU;WANG, CHIU-HWA;SHEN, MING-CHING;CHUANG, SOU-MING;TIEN, HWEI-FANG | en |
dc.date | 1998 | en |
dc.date.accessioned | 2009-01-20T06:24:34Z | - |
dc.date.accessioned | 2018-07-12T09:11:16Z | - |
dc.date.available | 2009-01-20T06:24:34Z | - |
dc.date.available | 2018-07-12T09:11:16Z | - |
dc.date.issued | 1998 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/103229 | - |
dc.description.abstract | Lymphoproliferative diseases of large granular lymphocytes ( LDGL) may arise from either CD3(+) T cells or CD3(-) natural killer (NK) cells. LDGL with clonal proliferation of large granular lymphoeytes (LGL) is defined as LGL leukaemia. The number of patients with NK-LGL leukaemia reported is limited and the pathogenesis of the disease is not yet clear. From 1991 to 1998 six patients with cytogenetically proved clonal disease of NK-LGL were identified in our institute. All were seropositive far Epstein-Barr virus (EBV). EBV RNA or DNA could be detected in LGL from four patients by EBV in situ hybridization or Southern blot analysis. Most patients ran an aggressive clinical course and five died of the disease. Nonrandom clonal chromosomal abnormalities, including duplication of 1q, rearrangement at 3q and loss of chromosomes Y, 13 or 10, were noted in the six patients from this study and in eight from the literature. The implications of these recurrent cytogenetic aberrations in the development and progression of the disease deserve further studies. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BRITISH JOURNAL OF HAEMATOLOGY v.103 n.4 pp.1124-1128 | en |
dc.relation.ispartof | BRITISH JOURNAL OF HAEMATOLOGY | - |
dc.title | Clonal Disease of Natural Killer-Large Granular Lymphocytes(Lgl) in Taiwan | en |
dc.relation.pages | 1124-1128 | - |
dc.relation.journalvolume | v.103 | - |
dc.relation.journalissue | n.4 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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