https://scholars.lib.ntu.edu.tw/handle/123456789/202194
標題: | High Prevalence of Antimicrobial Resistance in Rapidly Growing Mycobacteria in Taiwan | 作者: | YANG, SHUN-CHENG HSUEH, PO-REN LAI, HSIN-CHIH TENG, LEE-JENE HUANG, LI-MIN CHEN, CHUNG-MING WANG, SHU-KUAN HO, SHEN-WU LUH, KWEN-TAY 賴信志 陳中明 |
關鍵字: | NONTUBERCULOUS MYCOBACTERIA;CHELONAE INFECTION;CLINICAL- SIGNIFICANCE;BROTH MICRODILUTION;GENE SEQUENCE;FORTUITUM | 公開日期: | 2003 | 卷: | v.47 | 期: | n.6 | 起(迄)頁: | 1958-62 | 來源出版物: | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 摘要: | An increasing number of clinical isolations of rapidly growing mycobacteria (RGM) at the National Taiwan University Hospital were noted from 1992 to 2001. Broth microdilution MICs of 15 antimicrobial agents were determined for 200 clinical isolates of RGM, including the Mycobacterium fortuitum group (69 isolates), M. chelonae (39 isolates), and M. abscessus (92 isolates). Our results showed that the resistance rates of these isolates to the currently available agents were remarkably high. Amikacin was active against nearly all RGM isolates. Clarithromycin was usually active against M. abscessus (79% susceptibility) and the M. fortuitum group (65% susceptibility). The majority of M. fortuitum group isolates were susceptible to ciprofl oxacin (62%) and imipenem (61%) . The susceptibilities to other conventional anti-RGM agents of these isolates were poor but differed markedly by species. The newer fl uoroquinolones (levofloxacin, moxifloxacin, and gatifl oxacin) and meropenem showed better in vitro activities against the M. fortuitum group isolates than against the other two species of RGM. Linezolid had fairly good activity against these RGM isolates, particularly against M. chelonae isolates (82% susceptible). Telithromycin had poor activity against these RGM isolates ( the MICs at which 50% of the isolates tested are inhibited[ MIC50s] were 32 to 64 �g/ml, and the MIC90s were > 64μg/ml). |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/103386 |
顯示於: | 醫學系 |
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