https://scholars.lib.ntu.edu.tw/handle/123456789/202584
標題: | In Vitro Susceptibilities of Aerobic and Facultative Anaerobic Gram- Negative Bacilli Isolated from Patients with Intra-Abdominal Infections at a Medical Center in Taiwan: Results of the Study for Monitoring Antimicrobial Resistance Trends (Smart) 2002-200 | 作者: | CHEN, WEI-YU JANG, TSRANG-NENG HUANG, CHIEN-HSIEN HSUEH, PO-REN |
關鍵字: | beta-Lactamases;Drug resistance;bacterial;Enterobacteriaceae;Infections | 公開日期: | 2009 | 卷: | v.42 | 期: | n.4 | 起(迄)頁: | 317-323 | 來源出版物: | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION | 摘要: | BACKGROUND AND PURPOSE: The Study for Monitoring Antimicrobial Resistance Trends (SMART) was initiated to monitor the in vitro antimicrobial susceptibility of aerobic and facultative anaerobic Gram-negative bacilli (GNB) isolated from patients with intra-abdominal infections (IAI) . This report summarizes the SMART data from 1 of the study centers from 2002 to 2006. METHODS: 492 Gram-negative isolates were collected from 482 patients with IAI. Susceptibilities of these isolates to 12 antimicrobial agents were determined using the broth microdilution method. RESULTS: Enterobacteriaceae comprised 68.3% of the isolates (n = 336). The 4 main species were Klebsiella spp. (n = 129; 26.2%), Escherichia coli (n = 122; 24.8%), Enterobacter spp . (n = 36; 7.3%), and Aeromonas hydrophila (n = 35; 7.1%). The commonest glucose non-fermentative GNB were Acinetobacter baumannii (n = 46; 9.3%) and Pseudomonas aeruginosa (n = 35; 7.1%). Extended-spectrum beta-lactamase( ESBL) production was detected in 70 Enterobacteriaceae isolates (70/336; 21%). The ESBL phenotype was exhibited by 23% of Klebsiella pneumoniae, 26% of E. coli, and 19% of Enterobacter spp. The highest rate of ESBL production was found in 2005 for E. coli (38%) and in 2003 for Klebsiella spp. (38%) and Enterobacter spp. (40%). The incidence of ESBL-producing isolates declined in 2005 and 2006. Low susceptibility rates of E. coli isolates to ciprofloxacin ( 58%) and levofloxacin (64%) were noted. Ertapenem (99%), imipenem (99%), and amikacin (94%) were the most potent agents against Enterobacteriaceae spp. CONCLUSIONS: Continuous surveillance is crucial to monitor the trend of antimicrobial resistance patterns among GNB isolated from IAI. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/235665 |
顯示於: | 醫學系 |
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