https://scholars.lib.ntu.edu.tw/handle/123456789/203952
標題: | Fasting Serum Levels of Adiponectin, Ghrelin, and Leptin in Men with Spinal Cord Injury | 作者: | WANG, YEN-HO HUANG, TIEN-SHANG LIANG, HUEY-WEN SU, TA-CHEN CHEN, SSU-YUAN WANG, TZUNG-DAU |
關鍵字: | Adipocytes;Leptin;Rehabilitation;Spinal cord injuries | 公開日期: | 2005 | 卷: | v.86 | 期: | n.10 | 起(迄)頁: | - | 來源出版物: | ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION | 摘要: | Abstract Wang Y-H, Huang T-S, Liang H-W, Su T-C, Chen S-Y, Wang T-D. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Objectives To measure serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury (SCI) and to investigate possible correlations between these serum levels and various factors, such as body mass index (BMI), age, injury level, and duration of injury. Design Cross-sectional. Setting A university hospital that is a tertiary referral center. Participants Eighty-nine men with traumatic neurologically complete SCI (30 with tetraplegia, 59 with paraplegia) and 37 age- and BMI-matched male controls. Subjects with SCI were injured at the mean age ± standard error of 28.5±1.0 years (range, 14.7–59.1y) and the mean injury duration was 10.8±0.7 years (range, 1.1–27.7y). Interventions Not applicable. Main Outcome Measures Serum levels of adiponectin, ghrelin, and leptin and BMI. Results Serum leptin levels in subjects with SCI (mean, 7.0±0.5ng/mL) were significantly higher than those in able-bodied controls (mean, 4.7±0.6ng/mL) (P<.01). The group with tetraplegia had higher serum leptin levels than the group with paraplegia, but this did not reach a statistically significant level (8.2 ±1.1ng/mL vs 6.4±0.5ng/mL, P=.097). There were significant differences in serum leptin levels among the 3 groups by 1-way analysis of variance (P =.008). Serum adiponectin levels in subjects with SCI (7.1±0.5ng/mL ) were higher than those in able-bodied controls (5.6±0.5ng /mL), but this was not statistically significant (P=.08). In contrast, serum levels of ghrelin in subjects with SCI (302 .0±17.5pg/mL) were similar to those in the controls (264.0±27.0pg/mL) (P=.24). Serum leptin levels correlated positively with BMI (SCI, r=.698, P<.001; controls, r=.782, P<.001), whereas serum adiponectin (SCI, r=–.527, P<.001; controls, r=–.315, P=. 057) and ghrelin (SCI, r=–.368, P<. 001; controls, r=–.447, P=.006) levels correlated negatively with the BMI in both subjects with SCI and controls. Conclusions Men with SCI have significantly higher serum leptin levels than able-bodied controls, and serum leptin levels correlated with the degree of neurologic deficit. Men with SCI had a tendency toward higher serum adiponectin level than able-bodied controls. Serum levels of ghrelin in men with SCI were similar to those of controls. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/99413 |
顯示於: | 醫學系 |
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