https://scholars.lib.ntu.edu.tw/handle/123456789/204760
標題: | Rare Clinical Experiences for Surgical Treatment of Melanoma with Osseous Metastases in Taiwan | 作者: | HUANG, KOU-YUAN WANG, CHRONG-REEN YANG, RONG-SEN |
關鍵字: | MALIGNANT-MELANOMA;BONE METASTASES;PROGNOSTIC-FACTORS;MORTALITY;RECURRENT;SURVIVAL | 公開日期: | 2007 | 卷: | v.8 | 期: | 70 | 起(迄)頁: | - | 來源出版物: | BMC MUSCULOSKELET DISORD | 摘要: | Background: Malignant melanoma occurs infrequently in Taiwan . Once it has progressed into osseous metastases, the prognosis is poor. There are no reported clinical experiences of surgical management in this area. Methods: To improve our understanding of the rare clinical experiences, we retrospectively investigated clinical characteristics, radiological findings, treatment modalities, survival outcomes and prognoses of 11 Taiwanese patients with osseous metastasis of melanoma treated surgically at two national medical centers, National Taiwan University Hospital and National Cheng Kung University Hospital from January 1983 to December 2006 . Results: Six patients suffered from acral- lentiginous melanoma. Nine patients sustained multiple osseous metastases and most lesions were osteolytic. Nine patients also had sustained metastases to other organs including liver, lungs, lymph nodes, brain and spleen. Second malignancies including lung cancer, thyroid papillary carcinoma, renal cell carcinoma and cervical cancer co- existed in four patients. The interval from the initial diagnosis of melanoma to the clinical detection of osseous metastases varied from 0–37.8 months (mean 9.75 months). Metastatic melanoma was invariably fatal; the mean survival time from bone metastases to death was 5.67 months. Conclusion: Due to the high morbidity and poor survival of Taiwanese patients with osseous metastases of melanoma, surgical treatment should be directed towards pain relief and the prevention of skeletal debilitation in order to maintain their quality of life. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92443 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。