https://scholars.lib.ntu.edu.tw/handle/123456789/291998
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JIH-TAY HSU | en |
dc.creator | JIH-TAY HSU | en |
dc.date.accessioned | 2018-09-10T03:43:28Z | - |
dc.date.available | 2018-09-10T03:43:28Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-0034999671&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/291998 | - |
dc.description.abstract | This study examined the growth regulatory effects of a phyto-oestrogen, biochanin A, on a transformed human endothelial cell line ECV304 in vitro. Biochanin A was found to inhibit cell proliferation in a dose-dependent fashion and this effect was influenced by the concentration of serum present in the culture medium. In the absence of serum, the calculated IC50 of biochanin A was 0.18 ± 0.1 μM compared to an IC50 of 35 ± 5 μM at 10 % serum. At low cell density, the growth inhibitory effects of biochanin A were more evident than at high cell density. Co-administration of a synthetic oestrogen diethylstilboestrol with biochanin A did not suppress the growth regulatory effects of biochanin A treatment. We conclude that biochanin A inhibits the cell proliferation of human endothelial cells at concentrations that are physiologically achievable in vivo and that this effect may play an important role in the cancer-preventing activity of the phyto-oestrogens. | - |
dc.language | en | en |
dc.relation.ispartof | British Journal of Nutrition | en_US |
dc.source | AH | - |
dc.subject | Cell proliferation; Endothelial cells; Phyto-oestrogen | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biochanin A; diethylstilbestrol derivative; drug metabolite; genistein; phytoestrogen; article; cancer prevention; cell density; cell growth; cell proliferation; concentration response; culture medium; drug activity; drug antagonism; endothelium cell; growth inhibition; human; human cell; IC 50; in vitro study; in vivo study; inhibition kinetics; regulatory mechanism | - |
dc.title | Growth inhibition of human endothelial cells by the phyto-oestrogen biochanin A, a metabolite of genistein | - |
dc.type | journal article | en |
dc.identifier.scopus | 2-s2.0-0034999671 | - |
dc.relation.pages | 615-620 | - |
dc.relation.journalvolume | 85 | - |
dc.relation.journalissue | 5 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.orcid | 0000-0002-7701-3163 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 動物科學技術學系 |
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