https://scholars.lib.ntu.edu.tw/handle/123456789/292698
標題: | Cytotoxic dolabellane diterpenes from the Formosan soft coral Clavularia inflata | 作者: | Duh, C.-Y. Chia, M.-C. Wang, S.-K. Chen, H.-J. El-Gamal, A.A.H. CHANG-FENG DAI |
公開日期: | 2001 | 卷: | 64 | 期: | 8 | 起(迄)頁: | 1028-1031 | 來源出版物: | Journal of Natural Products | 摘要: | Six new cytotoxic dolabellane diterpenes, (1R*,12R*)-dolabella-4(16),7,10-triene-3,13-dione (1), (1R*,7R*,8S*,-12R*)-dolabella-4(16),10-diene-7,8- epoxy- 3,13-dione (2), (1R*,10R*,11S*,12R*)-dolabella-4(16),7-diene-10, 11-epoxy-3,13-dione (3), (1R*)-dolabella-4(16),7,11(12)-triene-3,13-dione (4), (1R*,3R*)-3-hydroxydolabella-4(16),7,11(12)-triene-3,13-dione (5), and (1R*,7R*)-7-hydroperoxydolabella-4(16),8(17),11(12)-triene-3, 13-dione (6), have been isolated from the Formosan soft coral Clavularia inflata. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0034861473&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/292698 |
DOI: | 10.1021/np010106n | SDG/關鍵字: | 3 hydroxydolabella 4(16),7,11(12) triene 3,13 dione; 7 hydroperoxydolabella 4(16),8(17),11(12) triene 3,13 dione; antineoplastic agent; cytotoxic agent; diterpene; dolabella 4(16),10 diene 7,8 epoxy 3,13 dione; dolabella 4(16),7 diene 10,11 epoxy 3,13 dione; dolabella 4(16),7,10 triene 3,13 dione; dolabella 4(16),7,11(12) triene 3,13 dione; unclassified drug; article; carbon nuclear magnetic resonance; coral; cytotoxicity; drug isolation; drug structure; human; human cell; proton nuclear magnetic resonance; spectroscopy; structure analysis; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cnidaria; Diterpenes; Humans; Leukemia P388; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Clavularia; Dolabella; Invertebrata |
顯示於: | 海洋研究所 |
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