https://scholars.lib.ntu.edu.tw/handle/123456789/313637
標題: | Oxidative status in patients with alcohol dependence: A clinical study in Taiwan | 作者: | FU-CHUO PENG | 公開日期: | 2005 | 卷: | 68 | 期: | 17-18 | 起(迄)頁: | 1497-1509 | 來源出版物: | Journal of Toxicology and Environmental Health - Part A | 摘要: | The aim of this study is to examine the relationship between alcohol dependence and oxidative status. The biochemical parameters and antioxidants status were measured among 28 patients with alcohol dependence. Nineteen healthy persons without drinking problem were recruited as the control subjects. The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyltransferase (γ-GT), and levels of cholesterol, triglyceride (TG), and uric acid were significantly increased in the specimen of patients compared with control. Serum malondialdehyde (MDA) levels of the patients were found to be significantly increased compared with controls and decreased after abstinence. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities were, respectively, 86% and 37% lower in alcoholic patients. After 14 d of abstinence, SOD activity was significantly reduced by 85%, CAT by 52%, and GPXby 54%, whereas no change was found in activity of glutathione reductase (GR). The duration of alcohol dependence is significantly correlated with the levels of MDA. In addition, the activity of CAT was significantly correlated with MDA levels. The results of this study suggest that oxidative stress occurred, during alcohol dependence and subsequently affected the antioxidants mechanisms. Copyright? Taylor & Francis Inc. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-26044442200&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/313637 |
DOI: | 10.1080/15287390590967432 | SDG/關鍵字: | alanine aminotransferase; alcohol; antioxidant; aspartate aminotransferase; cholesterol; gamma glutamyltransferase; glutathione peroxidase; glutathione reductase; malonaldehyde; superoxide dismutase; triacylglycerol; uric acid; alanine aminotransferase; aspartate aminotransferase; bilirubin; cholesterol; gamma glutamyltransferase; glutathione peroxidase; malonaldehyde; superoxide dismutase; triacylglycerol; adult; alcoholism; article; cholesterol blood level; clinical article; controlled study; enzyme activity; enzyme blood level; female; human; linear regression analysis; male; priority journal; Taiwan; triacylglycerol blood level; uric acid blood level; aged; alcoholism; blood; case control study; metabolism; middle aged; oxidative stress; Taiwan; Adult; Aged; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Bilirubin; Case-Control Studies; Cholesterol; Female; gamma-Glutamyltransferase; Glutathione Peroxidase; Humans; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Superoxide Dismutase; Taiwan; Triglycerides |
顯示於: | 毒理學研究所 |
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